Results 91 to 100 of about 1,167,396 (296)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement

Frontiers in Physiology, 2022
Objective: After coronary artery bypass grafting (CABG) surgery, the main causes of poor instant patency of left internal mammary arteries (LIMAs) are competitive flow and anastomotic stenosis, but how to determine the cause of LIMA non-patency without ...
Boyan Mao, Yue Feng, Yue Feng, Mengyao Duan, Yihang Dong, Gaoyang Li, Bao Li, Jincheng Liu, Yuting Guo, Minghui Wei, Zhou Zhao, Youjun Liu   +11 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The $(h,k)$-Server Problem on Bounded Depth Trees

, 2017
We study the $k$-server problem in the resource augmentation setting i.e., when the performance of the online algorithm with $k$ servers is compared to the offline optimal solution with $h \leq k$ servers.
Bansal, Nikhil, Eliáš, Marek, Jeż, Łukasz, Koumoutsos, Grigorios   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Randomized Competitive Analysis for Two Server Problems

Algorithms, 2008
We prove that there exists a randomized online algorithm for the 2-server 3-point problem whose expected competitive ratio is at most 1.5897. This is the first nontrivial upper bound for randomized k-server algorithms in a general metric space whose ...
Jun Kawahara, Kazuo Iwama, Wolfgang Bein
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Online makespan minimization for MapReduce scheduling on multiple parallel machines

Demonstratio Mathematica
In this work, we investigate the online MapReduce processing problem on mm uniform parallel machines, aiming at minimizing the makespan. Each job consists of two sets of tasks, namely, the map tasks and the reduce tasks.
Zheng Quanchang, Zhao Yueyang, Wang Jiahe   +2 more
doaj   +1 more source

Species Interactions Shape Nitrogen Utilization Characteristics and Influence Soil Quality in Jujube–Alfalfa Intercropping System

Plants
Intercropping legumes offers a sustainable approach to enhance resource efficiency and yields, yet the effects of different legume densities and nitrogen addition levels on soil quality within such systems remain unclear.
Hang Qiao, Hui Cheng, Tiantian Li, Wenxia Fan, Yaru Zhao, Zhengjun Cui, Jinbin Wang, Qingqing Yang, Chengze Jia, Wei Zhang, Guodong Chen, Sumei Wan   +11 more
doaj   +1 more source