Results 51 to 60 of about 18,824,229 (266)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Peculiarities of Pre-Competitive Psychological Factors, Sport Performance Indicators and Physiological Demands in Youth Golf

Baltic Journal of Sport and Health Sciences, 2018
Background. Sport performance indicators, physiological demands and psychological hallmarks are the key factors in the development of golf performance. However, no research was found in youth golf.
Marius Zienius, Antanas Skarbalius, Aurelijus Kazys Zuoza, Kazimieras Pukėnas   +3 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

Contribution of psychoemotional stress to the development of adaptational failure in the competitive period of qualified athletes

Acta Biomedica Scientifica, 2016
The electroencephalography can be used to obtain objective data on the level of situational anxiety in athletes. The dynamics of the psychoemotional state of the athletes during the annual training-competitive macrocycle is characterized by the following
K. P. Bazarin, A. A. Savchenko
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

STUDY ON THE LINK BETWEEN SELF-ESTEEM AND TEAM IDENTITY AS MAJOR FACTORS IN TACKLING COMPETITIVE ANXIETY IN PERFORMANCE ATHLETES

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae
Sports competition and athletic performance are of major interest in sports psychology. Throughout the history of sports, researchers have sought to identify the modifiable factors that could help those who take part in competition to adapt to it as ...
Francisc Remus DATCU, Simona Angela PETRACOVSCHI, Eugen BOTA, Martin Petru DOMOKOS   +3 more
doaj   +1 more source

Influence of psychoemotional stress on the functional activity of neutrophilic granulocytes and lipid peroxidation intensity in qualified athletes in competitive period

Acta Biomedica Scientifica, 2016
The EEG can be used to obtain objective data on the level of situational anxiety in athletes. The dynamics of the psycho-emotional state of the athletes during the annual training-competitive macrocycle is characterized by the following features: in the ...
K. P. Bazarin, A. A. Savchenko
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Ansiedade e desempenho: um estudo com uma equipe infantil de voleibol feminino Anxiety and performance: a study of an infant female volleyball team

Motriz: Revista de Educacao Fisica, 2010
O objetivo deste estudo foi analisar a 'ansiedade traço' e 'ansiedade estado' e sua relação com o desempenho pré-competitivo e competitivo no voleibol. O caso estudado foi uma equipe de voleibol feminina infantil.
Christi Noriko Sonoo, Anderson Luiz Gomes, Mara Laiz Damasceno, Schelyne Ribas da Silva, Mirieli Denardi Limana   +4 more
doaj   +1 more source