Results 61 to 70 of about 219,505 (253)

Ética, Etiqueta e Estratégia Organizacional: em busca do Elo Perdido

open access: yesRevista Espaço Acadêmico, 2011
  O presente artigo procura articular a aproximação e o diálogo, de forma exploratória, entre a ética, a etiqueta e a estratégia organizacional. Baseado nos pressupostos da perfectibilidade da Humanidade e do caráter aperfeiçoador da ética, o artigo ...
Paulo Hayashi Jr.
doaj  

Entrepreneurship and corporate competitiveness [PDF]

open access: yesMarketing (Beograd. 1991), 2005
Macroeconomics reforms are not enough for long-range stability. Transition enterprises in domestic economy hasn't prepare itself for the market economy. It has some specific characteristics which are analyzed in this paper. Entrepreneurship is the corner
Mihailović Božo
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Features of the Development Strategy Customer Relationship Management

open access: yesМодернизация, инновация, развитие, 2017
Purpose: in the current economic situation one of the main conditions of competitiveness of the company is its customer focus. In this regard, the most promising strategy for strengthening the stability of the organization is the management of customer ...
I. M. Gurova
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Innovative reference points in management of business competitiveness [PDF]

open access: yesMarketing i Menedžment Innovacij, 2010
In the article authors system of the analysis and the estimation of competitiveness of business subjects is presented. It is based on four elements: theory; law; principle; method. The model of competitive strategy is resulted, it is described with three
T.O. Zagornaja
doaj  

STRATEGY DEVELOPMENT FOR CREATING COMPETITIVE ADVANTAGES IN SMALL AND MEDIUM INDUSTRIES (SMIs)

open access: yesJurnal Aplikasi Manajemen, 2019
Currently, the increasingly dynamic industry development has caused business competition that cannot be avoided by business players, including by TRI as one of the SMIs in Purbalingga Regency, Indonesia.
Grisna Anggadwita   +2 more
doaj   +1 more source

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