Results 71 to 80 of about 219,505 (253)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Strategy for Ensuring Enterprise Competitiveness in the Sphere of Hotel Services [PDF]

Problemi Ekonomiki, 2018
The aim of the article is to study the process of forming a strategy to ensure competitiveness of an enterprise in the sphere of hotel services. The content of the concepts “competitiveness of an enterprise in the hotel industry”, “competitive advantage”
Zavidna Liudmyla D.
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Penguatan Kinerja Keuangan UKM melalui Aset Tidak Berwujud dan Strategi Bersaing

Jurnal Riset dan Aplikasi: Akuntansi dan Manajemen
: Strengthening SME Financial Performance through Intangible Assets and Competitive Strategies Purpose: the purpose of the article should be concise and presented in one sentence.
Aranta Prista Dilasari, Annita Mahmudah, Mesra Berlyn Hakim   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Digital Transformation: Unlocking New Dimensions in Manufacturing Efficiency

RUDN Journal of Economics
The manufacturing sector stands on the cusp of the digital revolution that holds the promise of fundamentally reshaping its operational landscape. This paper delves into the transformative journey of digital integration within the manufacturing realm ...
Jin Baiming, Robert O. Voskerichyan
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Fatores internos associados à decisão de diversificação nas cooperativas agropecuárias

Economia Aplicada, 2003
The incorporation of competitive strategies has been one of the several alternatives of the agricultural cooperatives in the search for gains in efficiency and competitiveness before the globalization ofthe markets. In this context, the central question
Marco Aurélio Marques Ferreira, Marcelo José Braga   +1 more
doaj  

Cost leadership strategies in low-cost airlines: A deep learning-based comparative analysis of Ryanair and Pegasus

Tourism
Air transportation plays a crucial role in the development of the global tourism industry, facilitating the movement of travellers across different regions and enhancing accessibility to tourism destinations.
Zehra Yardi, Emre Ozan Aksöz
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source