Results 51 to 60 of about 1,092,439 (295)
Indonesian Human Resources Readiness in term of Facing the ASEAN Economic Community
JSP: Jurnal Ilmu Sosial dan Ilmu Politik, 2016 This article explains about the dilemma which will be faced by Indonesia when the the Mutual Recognition Arrangement (MRA) is implemented in the ASEAN Economic Community (AEC) by the end of 2015.
Cinintya Audori Fathin +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
State of Implementation of Supply Chain Management in Companies in Romania [PDF]
Amfiteatru Economic, 2013 The aim of this study was to assess the degree of supply chain management`s development in Romanian companies. For this, a selective, explorative survey, on a sample of 225 Romanian companies was used.
Mihaela Dobrea, Cristinel Vasiliu
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A place-based approach in collaborative governance
Oñati Socio-Legal SeriesCollaborative governance is a broad concept that includes many forms of collaborative arrangements among various actors that differ in their nature, objectives, and types of interactions.
Miren Larrea +2 more
doaj +1 more source
THE ACTIVE INTEGRATED CIRCULAR PROCESS – EXPRESSION OF MAXIMUM SYNTHESIS OF SUSTAINABLE DEVELOPMENT [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 "The accelerated pace of economic growth, prompted by the need to ensure reducing disparities between the various countries, has imposed in the last two decades the adoption of sustainable development principles, particularly as a result of the Rio ...
Done Ioan , Matei Vasile, Matei Dorina
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source