Results 71 to 80 of about 731,458 (247)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The Beginning and Evolution of Quranic Sciences: A Research and Historical Review Authors

open access: yesپاکستان جرنل آف اسلامک فلاسفی, 2023
This study explores the introduction, significance, and excellence of the Holy Qur’an alongside the origins and development of ‘Uloom al-Qur’an (Qur’anic sciences).
Dr. Muhammad Zaid
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Development and reliability and validity test of self-efficacy scale for caregivers of type 2 diabetes

open access: yesHuli yanjiu, 2020
ObjectiveTo compile the self⁃efficacy scale for caregivers of type 2 diabetes patients and test its reliability and validity,in order to provide a tool for assessing the self⁃efficacy of diabetic caregivers.MethodsA pool of entries was formed on the ...
DAI Qi, DING Yaping, XU Jingjing, YU Jie
doaj  

Pengembangan Bahan Ajar Kompilasi Fisika Matematika II Pokok Bahasan Persamaaan Diferensial Untuk Meningkatkan Penalaran Matematis

open access: yesJPFT (Jurnal Pendidikan Fisika dan Teknologi), 2017
This study aims to develop and produce teaching materials compilation of mathematical physics II on the subject of differential equations. Teaching materials that have been developed in the form of teaching modules.
I Wayan Gunada   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Management techniques - A compilation [PDF]

open access: yes
Engineering, finance, and personnel management methods and computer techniques for cost reduction and reliability in project ...

core   +1 more source

A Compilation Target for Probabilistic Programming Languages [PDF]

open access: yes, 2014
Forward inference techniques such as sequential Monte Carlo and particle Markov chain Monte Carlo for probabilistic programming can be implemented in any programming language by creative use of standardized operating system functionality including ...
Paige, Brooks, Wood, Frank
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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