Results 151 to 160 of about 37,010 (319)
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang+13 more
wiley +1 more source
A full-stack memristor-based computation-in-memory system with software-hardware co-development. [PDF]
Yu R+14 more
europepmc +1 more source
Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba+15 more
wiley +1 more source
Drug Resistance Predictions Based on a Directed Flag Transformer
CAPTURE, a deep learning framework combining structural and sequence data to predict drug‐resistant Mpro mutations, revealing that PAXLOVID use may be accelerating resistance—supporting real‐time viral surveillance and therapeutic design. Abstract The evolving SARS‐CoV‐2 virus threatens global public health, particularly with potential resistance to ...
Dong Chen+8 more
wiley +1 more source
Protocol to study brain dynamics of mammals through the hierarchy of complex correlation patterns defining a robust functional architecture. [PDF]
Varga L+11 more
europepmc +1 more source
During object grasping in macaques, information flow between the primary sensory cortex (S1) and the primary motor cortex (M1) is modulated by tactile properties of the target. Intracortical micro‐stimulation in S1 reliably evokes M1 responses that resemble those naturally generated during grasping under specific tactile conditions.
Qi Zhang+9 more
wiley +1 more source