Results 331 to 340 of about 905,894 (352)
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Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse
Immunogenetics, 1990The expression of the fourth component of complement (C4) of the mouse can differ 20-fold and is determined by C4-high (C4h) or C4-low (C4l) alleles. To investigate the molecular mechanisms underlying the differences in C4 expression, we compared the transcriptional activity of the C4 genes between high and low C4-producer strains of mice (B10 and FM ...
Morinobu Takahashi +5 more
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New DNA sequences for the human complement gene C4
Molecular Immunology, 1993In order to increase the knowledge on the human Cl genes polymorphism, sequencing of the most variable region (CM) has been carried out in four Tenth International Histocompatiiility Workshop iymphoblastoid cell lines: PLH, LKT3, YAR and DBB. Barn HI 926 bp fragments were amplifled (Belt et ai., 1985) using specific flanking primers (L3 and LA, Braun ...
Miguel Alvarez Y Antonio Arnaiz Villena +7 more
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Precursor complement protein (pro-C4) is converted in vitro to native C4 by plasmin
Nature, 1980The fourth component of complement (C4) is a constituent of the classical serum complement pathway, one of the principle effectors of inflammatory reactions. A single chain protein (molecular weight (MW) 200,000), presumed to be the precursor of C4 (pro-C4), was first identified as a product of cell-free translation on polysomes from guinea pig liver ...
Gabriel Goldberger, Harvey R. Colten
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Biology and Genetics of Complement C4
2008This review is organized in two parts. In the first part, I attempt to highlight my initial efforts to clone complement component C4 while a post-doctoral fellow with Professor Rodney R. Porter in the MRC Immunochemistry Unit and the Biochemistry Department at Oxford University from 1980 to 1985.
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Complement Components C3 and C4
2008I stayed in the Immunochemistry Unit from 1981 to 2002. It all started with an incident that happened in Hong Kong in 1980. I was working in the Department of Genetics, Washington University School of Medicine, with Paul Levine, who was my PhD thesis supervisor at Harvard.
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HLA-DQ, DR and complement C4 variants in systemic lupus erythematosus.
British Journal of Rheumatology, 1993We have defined HLA-DQA, DQB, DR and complement C4 variants in 92 subjects with SLE and 73 controls. Subjects with SLE showed an increased frequency of HLA-DQA*0501 (P < 0.01 corrected, odds ratio (OR) = 4.97; 95% C.I.
E. Davies +8 more
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Organization and Evolution of the Mouse Complement C4 Isotypes
1985Abstract Sequence comparisons of cDNA and genomic clones assigned to each of the two isotypes C4 and C4-Slp ( S ex L imited P rotein) allow to reconstruct the evolutionary history of the analogous isotypes of other mammals. Testosterone regulation of C4-Slp was probably acquired as a direct consequence of the mouse C4 gene duplication, an ...
Mario Tosi +3 more
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COMPLEMENT C4 ALLOTYPES IN ALZHEIMER'S DISEASE
The Lancet, 1982Richard Mayeux +2 more
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Complement C4 types in coeliacs and controls
Irish Journal of Medical Science, 1991F. M. Stevens, C. F. McCarthy, J Cahill
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