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Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance [PDF]

Iranian Journal of Immunology, 2023
Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement system affect the therapeutic approaches?” and “Do we consider complement inhibitors in therapeutic protocols?”.
Mehdi Torabizadeh, Helia Modaresi Asfeh, Zeinab Deris Zayeri, Cerdan Dominique, Hashem Kazemi, Najmaldin Saki   +5 more
doaj   +1 more source

Eculizumab in the Treatment of Aquaporin-4 Seronegative Neuromyelitis Optica Spectrum Disorder: A Case Report

Frontiers in Neurology, 2021
Objective: To report the case of a 35-year-old woman with treatment-resistant aquaporin-4 (AQP-4) immunoglobulin G (IgG) seronegative neuromyelitis optica spectrum disorder (NMOSD) successfully treated with eculizumab (a terminal complement inhibitor ...
Lakshmi Digala, Nakul Katyal, Naureen Narula, Raghav Govindarajan   +3 more
doaj   +1 more source

Neuromyelitis Optica Spectrum Disorders: Clinical Perspectives, Molecular Mechanisms, and Treatments

Applied Sciences, 2023
Neuromyelitis optica (NMO) is a rare autoimmune inflammatory disorder affecting the central nervous system (CNS), specifically the optic nerve and the spinal cord, with severe clinical manifestations, including optic neuritis (ON) and transverse myelitis.
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Arumugam Radha, Periyanaina Kesika, Chaiyavat Chaiyasut   +4 more
doaj   +1 more source

The Inhibition of Complement System in Formal and Emerging Indications: Results from Parallel One-Stage Pairwise and Network Meta-Analyses of Clinical Trials and Real-Life Data Studies

Biomedicines, 2020
This manuscript presents quantitative findings on the actual effectiveness of terminal complement component 5 (C5) inhibitors and complement component 1 (C1) esterase inhibitors through their formal and common “off-label” (compassionate) indications. The
Coralina Bernuy-Guevara, Hassib Chehade, Yannick D. Muller, Julien Vionnet, François Cachat, Gabriella Guzzo, Carlos Ochoa-Sangrador, F. Javier Álvarez, Daniel Teta, Débora Martín-García, Marcel Adler, Félix J. de Paz, Frank Lizaraso-Soto, Manuel Pascual, Francisco Herrera-Gómez   +14 more
doaj   +1 more source

Atypical hemolytic uremic syndrome: pathophysiology, clinical presentation, and treatment strategies [PDF]

Childhood Kidney Diseases
Atypical hemolytic uremic syndrome (aHUS) is a rare and potentially life-threatening thrombotic microangiopathy, characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Ji Yeon Song
doaj   +1 more source

Angioedema hereditario en Medellín, Colombia: evaluación clínica y de la calidad de vida

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. El angioedema hereditario es una inmunodeficiencia primaria de carácter autosómico dominante, debida a un déficit en la proteína inhibidora del factor C1 y caracterizada por episodios recurrentes de edema subcutáneo y de las mucosas.
María Dulfary Sánchez, Julián Cuervo, Deisi Rave, Gustavo Clemen, Juan José Yepes-Núñez, Blanca Ortiz-Reyes, Sara Sus, Ricardo Cardona   +7 more
doaj   +1 more source

Desensitization: Overcoming the Immunologic Barriers to Transplantation

Journal of Immunology Research, 2017
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after ...
Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan   +5 more
doaj   +1 more source

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling

mBio
Many bacterial toxins exert their cytotoxic effects by enzymatically inactivating one or more cytosolic targets in host cells. To reach their intracellular targets, these toxins possess functional domains or subdomains that interact with and exploit ...
Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk   +4 more
doaj   +1 more source

Efficacy analysis of iptacopan in a patient with thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation: a case report. [PDF]

Front Immunol
Zhao Z, Guo L, Ge J, Wu W, Yue Y, Qiu Y, Li F, Hua W, Gu W, Lin Y.   +9 more
europepmc   +1 more source

Complement C5 Inhibitor Ameliorates a Case of Dysferlinopathy. [PDF]

Neurol Neuroimmunol Neuroinflamm
Kang S, Wang Q, Lv H, Deng J, Zhang W, Lu X, Yuan Y, Wang Z, Zheng F, Yu M.   +9 more
europepmc   +1 more source