Biotechnology Progress, EarlyView.Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg +8 more
wiley +1 more source
Reprogramming innate immunity through viral interference: A double-edged strategy for enhancing and containing gene therapies. [PDF]
Mol Ther Nucleic AcidsLiu Z, Song S.
europepmc +1 more source
Functionalizing Conductive Diamond: Recent Advance in Fabrication, Modifications, and Applications
Carbon Energy, EarlyView.This review highlights recent advancements in the synthesis, modification, and electrochemical applications of conductive diamond, particularly boron‐doped diamond (BDD). It emphasizes progress in fabrication methods, including CVD and HPHT, and explores modifications such as doping, surface terminations, and composite design, enabling significant ...
Ning Linghu, Xin Jiang, Jing Xu
wiley +1 more source
Epidemiology and care management of Paroxysmal Nocturnal Hemoglobinuria (PNH) in a real-world setting in France: Description from the French National Hospitalization Database. [PDF]
PLoS OnePeffault de Latour R +7 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Repurposing Tumor Cells: A Paradigm Shift in Cell-Based Therapies for Cancer. [PDF]
Clin Cancer ResChen KS, Lin LY, Chen YC, Shah K.
europepmc +1 more source
Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches
Chemistry – A European Journal, EarlyView.We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal +4 more
wiley +1 more source
Characteristics and clinical courses of patients with atypical haemolytic uraemic syndrome on dialysis withdrawal after eculizumab treatment: sub-analysis of post-marketing surveillance in Japan. [PDF]
J NephrolIto S +4 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz +3 more
wiley +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab. [PDF]
Ann Clin Transl NeurolGerischer L +14 more
europepmc +1 more source