Subinhibitory concentrations of trimethoprim and sulfamethoxazole prevent biofilm formation by Acinetobacter baumannii through inhibition of Csu pilus expression [PDF]
, 2017 Acinetobacter baumannii is emerging as a multidrug-resistant nosocomial pathogen of increasing threat to human health worldwide. Pili are important bacterial virulence factors, playing a role in attachment to host cells and biofilm formation.
Feldman, Mario F +2 more
core +2 more sources
Effect of Different Media on the Bactericidal Activity of Colistin and on the Synergistic Combination With Azidothymidine Against mcr-1-Positive Colistin-Resistant Escherichia coli [PDF]
, 2020 Antimicrobial susceptibility testing (AST) performed according to defined guidelines is important to identify resistance and to predict the clinical success or failure of specific antibiotic therapy.
Coates, A +4 more
core +1 more source
The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]
, 2008 Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Passel, M.W.J., van +2 more
core +2 more sources
Unraveling How Candida albicans Forms Sexual Biofilms. [PDF]
, 2020 Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms.
Hernday, Aaron D +2 more
core +1 more source
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies [PDF]
, 2018 Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating
Burbelo +14 more
core +1 more source
Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2/iNOS and NF-κB/p300 signaling pathways. [PDF]
, 2014 Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers.
Deng, Wuguo +10 more
core +4 more sources
Identification of Naegleria fowleri proteins linked to primary amoebic meningoencephalitis [PDF]
, 2017 Naegleria fowleri (N. fowleri) causes primary amoebic meningoencephalitis, a rapidly fatal disease of the central nervous system. N. fowleri can exist in cyst, flagellate or amoebic forms, depending on environmental conditions.
Cabral, Guy A +4 more
core +2 more sources
Biological activities specified by antibiotic resistance plasmids [PDF]
, 2014 Bacteria can display resistance to a wide spectrum of noxious agents and environmental conditions, and these properties are often mediated by genes located on extrachromosomal DNA elements called plasmids.
Gonzalez-Carrero, Manuel I. +3 more
core +11 more sources
Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Sanhaji, Mourad +4 more
core +2 more sources