Results 81 to 90 of about 21,407 (223)

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Panspermia, Past and Present: Astrophysical and Biophysical Conditions for the Dissemination of Life in Space

, 2010
Astronomically, there are viable mechanisms for distributing organic material throughout the Milky Way. Biologically, the destructive effects of ultraviolet light and cosmic rays means that the majority of organisms arrive broken and dead on a new world.
A.A. Sharov, A.D. Panov, A.J. Nicastro, B.C. Clark, C. Mileikowsky, C. Woese, C.E. Cleland, C.T. Russell, D. Warmflash, E. Argyle, E. Rabbow, E. Willerslev, E.V. Koonin, F. Hoyle, F. Hoyle, F.C. Adams, F.H.C. Crick, G. Basri, G. Horneck, G. Horneck, G. Horneck, G. Horneck, G. Horneck, G. Marcy, H. Kuhn, H.D. Mennigman, H.J. Melosh, H.J. Melosh, J. Nagyvary, J. Overmann, J. Parnell, J. Scalo, J. Secker, J.D. Barrow, J.M. Greenberg, J.M. Overduin, J.T. Trevors, J.W. Schopf, K. Dose, K. Dose, L. Spitzer, M. Burchell, M. Burchell, M. Valtonen, M.H. Hart, M.K. Wallis, N. Meyer-Vernet, N.J. Dimmock, P. Weber, P.S. Wesson, P.S. Wesson, P.S. Wesson, P.S. Wesson, Paul S. Wesson, R. Shapiro, R.D. Noetzel, R.E. Dickerson, R.H. Vreeland, R.W. Court, S. Arrhenius, Steering Group, T. Lindahl, W.K. Hartmann, W.L. Nicholson, W.M. Napier, Z.P. Zagorski   +65 more
core   +1 more source

Self‐Sustaining Piezozyme Platform for Antifouling via Mechanically Triggered Enzymatic Cascade

Advanced Science, EarlyView.
Wave‐powered CeO2/g‐C3N4 piezozyme coating converts ocean motion into an enzymatic H2O2‐to‐ROS cascade, realizing 180‐day eco‐friendly marine antifouling. ABSTRACT Harnessing ubiquitous mechanical energy for catalytic activation offers an emerging pathway toward self‐sustaining environmental protection systems.
Jingyu Wang, Yanjun Yu, Rongxin Su, Jiangjiexing Wu   +3 more
wiley   +1 more source

Elastase and its Inhibitors in Intensive Care Medicine [PDF]

, 1990
Fritz, Hans, Jochum, Marianne
core   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Proteinases [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Neuhof, H., Redl, H., Schlag, Günther   +5 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Tests on medical microbiology [PDF]

, 2013
МИКРОБИОЛОГИЯ ...
Generalov, I. I., Zheleznyak, N. V.
core