A Targeted Blockade of Terminal C5a Is Critical to Management of Sepsis and Acute Respiratory Distress Syndrome: The Mechanism of Action of Vilobelimab. [PDF]
McCarthy MW +3 more
europepmc +1 more source
Advances in Complement Inhibitory Strategies for the Treatment of Glomerular Disease: A Rapidly Evolving Field. [PDF]
Conversano E, Vivarelli M.
europepmc +1 more source
Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy. [PDF]
Zhou XJ.
europepmc +1 more source
Advantages of using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases. [PDF]
Firdaus NHW +3 more
europepmc +1 more source
Therapeutic strategies targeting complement in myasthenia gravis patients. [PDF]
Wang Y, Nao J, Duan Y, Li Z, Feng J.
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Current Understanding of the Pathogenesis of ANCA-Associated Vasculitis and Novel Treatment Options Targeting Complement Activation. [PDF]
Drouzas K +3 more
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The complement alternative pathway and hemostasis
Immunological Reviews, 2022SummaryThe complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection by pathogens and halt bleeding at the site of vascular injury.
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The Complement Alternative Pathway and Preeclampsia
Current Hypertension Reports, 2018Significant and intricate immune adaptations are essential for the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid, potentially life-threatening disease for both mother and neonate that occurs uniquely in pregnancy, at least in part, due to maternal immune maladaptation.
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Alternative Complement Pathway in Schizophrenia [PDF]
In the present study, we evaluated functional activity of the alternative pathway of complement in schizophrenia by measuring the alternative pathway hemolytic activity (AH50) of complement as well as hemolytic activity of the complement C3 component (C3H50) in the blood of patients with schizophrenia and healthy subjects.
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