Results 291 to 300 of about 474,325 (341)

The alternative pathway of complement and the thrombotic microangiopathies

Transfusion and Apheresis Science, 2016
Thrombotic microangiopathies (TMA) are disorders defined by microangiopathic hemolytic anemia, non-immune thrombocytopenia and have multi-organ involvement including the kidneys, brain, gastrointestinal, respiratory tract and skin. Emerging evidence points to the central role of complement dysregulation in leading to microvascular endothelial injury ...
Chia Wei Teoh, Magdalena Riedl, Christoph Licht   +2 more
openaire   +3 more sources

Alternative pathway of complement in multiple myeloma

American Journal of Hematology, 1981
AbstractThe alternative pathway of complement was studied in 16 newly diagnosed and 2 previously treated patients with multiple myeloma. Functional activity of this pathway was abnormal in 10 of these 18 patients (55%). These abnormalities correlated with depressed levels of alternative pathway components in 3 of 10 patients, but in the remaining 7, no
Eric H. Kraut, Arthur L. Sagone
openaire   +3 more sources

Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy.

New England Journal of Medicine
BACKGROUND The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway.
Vlado Perkovic, Jonathan Barratt, Brad H. Rovin, Naoki Kashihara, Bart Maes, Hong Zhang, Hernán Trimarchi, D. Kollins, O. Papachristofi, Severina Jacinto-Sanders, Tobias Merkel, Nicolas Guerard, Ronny W. Renfurm, Thomas Hach, Dana V. Rizk   +14 more
semanticscholar   +1 more source

The Alternative Pathway of Complement Activation

1976
Publisher Summary This chapter presents the alternative pathway of complement activation. Two pathways for the recruitment of complement and its biological activities exist in plasma and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1 with immune complexes containing antibodies of the immunoglobulin G (IgG ...
Otto Götze, Hans J. Müller-Eberhard
openaire   +3 more sources

The role of antibody in the activation of the alternative complement pathway

Springer Seminars in Immunopathology, 1983
The alternative complement pathway can be activated in the absence of specific antibody by the surface of certain cells and particles that provide a microenvironment in which the affinity of the regulatory protein H for surface-bound Cab is low. There is now abundant evidence that antibody can enhance activation.
Douglas T. Fearon, K F Austen, W D Ratnoff   +2 more
openaire   +3 more sources

Mechanism of alternative complement pathway dysregulation by a phosphorothioate oligonucleotide in monkey and human serum.

Nucleic Acid Therapeutics, 2014
The species sensitivity and mechanism of complement pathway activation by a phosphorothioate oligonucleotide were investigated in monkey and human serum. Increasing concentrations of a phosphorothioate oligonucleotide, ISIS 2302, were incubated in either
Scott P. Henry, M. Jagels, Tony E. Hugli, Sheri Manalili, Richard S. Geary, Patricia C. Giclas, Arthur A. Levin   +6 more
semanticscholar   +1 more source

Regulation of the alternative pathway of complement by pH.

The Journal of Immunology, 1987
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia. The abnormal PNH erythrocytes are highly susceptible to complement-mediated lysis in vitro, especially at pH 6.4. Lysis has been shown to be due to alternative pathway activation. The purpose of this study was to determine why lysis of PNH erythrocytes is
Z, Fishelson, R D, Horstmann, H J, Müller-Eberhard   +2 more
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A TODDLER WITH ALTERNATIVE PATHWAY COMPLEMENT DEFICIENCY

Annals of Allergy, Asthma & Immunology, 2018
Introduction Complement system is an important component of innate immunity and can be activated through the classical, alternative, and lectin pathways. Patients with complement deficiency (CD) usually present with autoimmune disorders or recurrent infections.
P. Sriaroon, P. Purswani
openaire   +2 more sources

Activation of the Alternative Complement Pathway by Torulopsis Glabrata

Scandinavian Journal of Infectious Diseases, 1979
Torulopsis glabrata is a yeast-like fungus with increasing importance as an opportunistic human pathogen. The role of serum complement in resistance to this infection was studied by chemotactic and opsonic assays. The results indicate that T. glabrata activates complement via the alternative pathway.
Antonio Ferrante, Y.H. Thong
openaire   +2 more sources

Activation of the alternative pathway of complement by microcrystalline cholesterol

Atherosclerosis, 1980
Microcrystalline cholesterol in either the anhydrous or monohydrate form was a potent activator of the alternative pathway of complement as measured by the electrophoretic conversion (crossed immunoelectrophoresis) of C3 and properdin factor B. Chelation with 0.01 M ethylene-diaminetetraacetate (EDTA) completely eliminated conversion, but 0.01 M ...
Jeanie L. Hahn, Peter Hasselbacher
openaire   +3 more sources