Results 301 to 310 of about 474,325 (341)

Regulation of the alternative pathway of human complement by C1q

Molecular Immunology, 1987
The interaction of C1q with C3b and its effect on C3b activities in the alternative pathway of complement (APC) have been studied. Purified C1q markedly inhibited C3b deposition on and lysis of rabbit erythrocytes by the isolated cytolytic APC. It also blocked formation of the C3 convertase, C3b, Bb as well as binding of Factors B and H to sheep ...
Zvi Fishelson, Hans J. Müller-Eberhard
openaire   +3 more sources

The spectrum of complement alternative pathway‐mediated diseases

Immunological Reviews, 2008
Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
openaire   +2 more sources

Faculty Opinions recommendation of Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2020
Richard Smith
semanticscholar   +1 more source

Alternative Modes and Pathways of Complement Activation

1977
Complement (C) originally was detected by its ability to bring about cytolysis of antibody-sensitized bacteria and erythrocytes. Its name is derived from this ability to complement certain reactivities initiated by antibody. At least eleven С proteins, acting sequentially, are involved in mediating the usual antibody-initiated hemolysis. These proteins
Henry Gewurz, Thomas F. Lint
openaire   +2 more sources

Alternative complement pathway activation in thrombotic microangiopathy associated with lupus nephritis

Clinical Rheumatology, 2020
J. Mejía-Vilet, I. Gómez-Ruiz, C. Cruz, R. A. Méndez-Pérez, Roque A. Comunidad-Bonilla, N. Uribe-Uribe, C. Núñez-Álvarez, L. Morales-Buenrostro   +7 more
semanticscholar   +1 more source

Polyions regulate the alternative amplification pathway of complement

Immunopharmacology, 1983
Polyanion has previously been shown to inhibit generation of amplification pathway convertase of complement and to inhibit H-mediated decay of this complex. Polycations, protamine sulfate, and poly-l-lysine (PLL) were examined in this study for direct effects on alternative amplification pathway mechanisms and for ability to regulate polyanion-induced ...
openaire   +3 more sources

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980
Publisher Summary This chapter presents the proteins of the alternative pathway and their special properties as enzymes, enzyme substrates, and regulators. The participation with the classical pathway components, C5–C9, in membrane attack is considered.
Robert D. Schreiber, Hans J. Müller-Eberhard   +1 more
openaire   +3 more sources

Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy

Pediatric nephrology (Berlin, West), 2018
M. Noris, R. Donadelli, G. Remuzzi
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Paulo Cáceres Guido, Jun J Mao, Lorenzo Cohen   +2 more
exaly  

The alternative complement pathway in chickens

Developmental & Comparative Immunology, 1983
Leif Kongerslev, Lisbeth Bjerring Jensen, Claus Koch   +2 more
openaire   +2 more sources