Results 131 to 140 of about 3,236,190 (349)

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

, 2018
Jenny U. Johansson, William D. Brubaker, Harold S. Javitz, Andrew W. Bergen, Denise Nishita, Abhishek Trigunaite, Andrés B Crane, Justine Ceballos, Diego Mastroeni, Andrea J. Tenner, Marwan N. Sabbagh, Joseph Rogers   +11 more
openalex   +2 more sources

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor [PDF]

, 2022
Olivia J. S. Macleod, Alexander D. Cook, Helena Webb, Mandy Crow, Roisin Burns, Maria Redpath, Stefanie Seisenberger, Camilla Trevor, Lori Peacock, Angela Schwede, Nicola Kimblin, Amanda Fortes Francisco, Julia Pepperl, Steve Rust, Paul Voorheis, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington   +18 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1

, 2005
Matthew J. Cotter, Anne K. Zaiss, Daniel A. Muruve   +2 more
openalex   +1 more source

Ligation of complement receptor 1 increases erythrocyte membrane deformability [PDF]

, 2010
Aleksandra M. Glodek, Rossen Mirchev, David E. Golan, Joseph Khoory, Jennie M. Burns, Sergey S. Shevkoplyas, A Nicholson-Weller, Ionita Ghiran   +7 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Phagocytic functions of microglial cells in the central nervous system and their importance in two neurodegenerative diseases: multiple sclerosis and Alzheimer’s disease

Open Life Sciences, 2006
Choucair Nada, Laporte Vincent, Levy Rachel, Arnold Anne-Sophie, Gies Jean-Pierre, Poindron Philippe, Lombard Yves   +6 more
doaj   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

CTx001 for Geographic Atrophy: A Gene Therapy Expressing Soluble, Truncated Complement Receptor 1 (Mini-CR1). [PDF]

Ophthalmol Sci
Rathi S, Didangelos A, Pisarenka S, Green R, Zafeiri S, Emery-Billcliff P, Patel N, Whalley P, Zamiri P, Tilakaratna V, Szula E, Hasan R, Munye MM, Unwin RD, Bishop PN, Keefe D, Clark SJ.   +16 more
europepmc   +2 more sources