Results 171 to 180 of about 1,125,763 (339)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Complementary and Alternative Medicine (CAM) Among Hypertensive Patients in Northern Nigeria

, 2020
Abdulgafar Olayiwola Jimoh, Aminu Yusuf Faragai, Umar Tukur, Zuwaira Sani   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The use of Complementary/Alternative Medicine among the general population in Tehran, Iran

Payesh, 2008
Objective(s): This study was conducted to assess the prevalence of CAM use in Tehran, Iran. Methods: This cross sectional study was carried out on 6148 citizens of Tehran by cluster sampling.
Tehrani Banihashemi S.A., Asgharifard H., Haghdoost A.A., Barghmadi M., Mohammadhosseini N.   +4 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Probiotics as a Complementary Medicine in Neurologic Disorders. [PDF]

Health Sci Rep
Jafari M, Alipour M, Zamani S, Mohtasham Amiri A, Pourabbas P, Hasannejad-Bibalan M.   +5 more
europepmc   +1 more source

Complementary/alternative medicine: engulfed by postmodernism, anti-science and regressive thinking [PDF]

, 2009
Edzard Ernst
openalex   +1 more source

Complementary and Alternative Medicines for Cancer

, 2022
Alejandro Turek, Adrián Pablo Huñis
openalex   +1 more source

The Regulation of Alternative and Complementary Medicine [PDF]

The 21st century has seen the rapid growth of the Complementary and Alternative Medicine (CAM) sector (Hoffman, 2008). This is matched by an equally enthusiastic reception from the public (Molassiotis et al., 2005; Scott et al., 2005).
Choong, Kartina Aisha, Duckworth, Jean Ellen   +1 more
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