TITE-CLRM: Towards efficient time-to-event dose-escalation guidance of multi-cycle cancer therapies [PDF]
arXivTreatment of cancer has rapidly evolved over time in quite dramatic ways, for example from chemotherapies, targeted therapies to immunotherapies and chimeric antigen receptor T-cells. Nonetheless, the basic design of early phase I trials in oncology still follows pre-dominantly a dose-escalation design.
arxiv
HIV, Cardiovascular Diseases, and Chronic Arsenic Exposure co-exist in a Positive Synergy [PDF]
arXiv, 2016 Recent epidemiological evidences indicate that arsenic exposure increases risk of atherosclerosis, cardiovascular diseases and microangiopathies in addition to the serious global health concern related to its carcinogenic effects. In experiments on animals, acute and chronic exposure to arsenic directly correlates cardiac tachyarrhythmia, and ...
arxiv
Alternative Therapies and Medical Science: Designing Clinical Trials of Alternative/Complementary Medicines—Is Evidence‐Based Traditional Chinese Medicine Attainable? [PDF]
, 2000 Julia Critchley +4 more
openalex +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source
Critical review of patient outcome study in head and neck cancer radiotherapy [PDF]
arXivRapid technological advances in radiation therapy have significantly improved dose delivery and tumor control for head and neck cancers. However, treatment-related toxicities caused by high-dose exposure to critical structures remain a significant clinical challenge, underscoring the need for accurate prediction of clinical outcomes-encompassing both ...
arxiv
Alternative and complementary medicine: A source of improved therapies for asthma? A challenge for redefining the specialty? [PDF]
, 2000 Renata J.M. Engler
openalex +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Dual-Energy Cone-Beam CT Using Two Complementary Limited-Angle Scans with A Projection-Consistent Diffusion Model [PDF]
arXivBackground: Dual-energy imaging on cone-beam CT (CBCT) scanners has great potential in different clinical applications, including image-guided surgery and adaptive proton therapy. However, the clinical practice of dual-energy CBCT (DE-CBCT) has been hindered by the requirement of sophisticated hardware components.
arxiv
The cellular uptake mechanism of SPIONs: an in-vitro study [PDF]
arXiv, 2018 The Superparamagnetic Iron Oxide Nanoparticles (SPIONs) of sizes ranging from 10-50 nm are being used in a large number of biological studies because of their peculiar characteristics of inducing local hyperthermia, MR imaging, specific targeting and drug delivery.
arxiv
The Effects of Complementary Therapies on Patient-Reported Outcomes: An Overview of Recent Systematic Reviews in Oncology. [PDF]
Cancers (Basel), 2023 Mentink M +5 more
europepmc +1 more source