Results 181 to 190 of about 1,318,648 (300)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Regulation of complementary medicine practitioners in Australia : Chinese medicine as a case example

, 2002
Complementary and alternative medicine (CAM) forms a significant part of the health economy. CAM practices are under increased scrutiny from consumers, clinicians, scientists and regulators.
Bensoussan, Alan, Carlton, Anne-Louise
core  

Complementary therapies for the management of attention deficit hyperactivity disorder in children: a scoping review. [PDF]

Rev Lat Am Enfermagem
Szychta LF, Sombra SEL, Lima GA, Ventura MWS, Oliveira BSB, Lima FET.   +5 more
europepmc   +1 more source

Early ambulation and dhikr complementary therapies effect on intestinal peristaltic in post-open cholecystectomy patients. [PDF]

Rev Bras Enferm, 2023
Wilandika A, Gartika N, Nurfarida E.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Alternative and Complementary Therapies: A Review Exploring the Role of Yoga and Ayurveda-based Herbal Medicines in Alleviating Hypothyroidism and Its Neuropsychiatric Manifestations. [PDF]

Ann Neurosci
Jaglan G, Balkrishna A, Varshney A.
europepmc   +1 more source

Current Status of Complementary Therapies Provided by Hospice Palliative Care in South Korea. [PDF]

J Hosp Palliat Care, 2021
Kwon S, Bak J, Kwon SH.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Integrative Approaches to Ovulation Induction in Polycystic Ovary Syndrome: A Narrative Review of Conventional and Complementary Therapies. [PDF]

Biomedicines
Song SY.
europepmc   +1 more source

How best to capture the impact of complementary therapies in palliative care: A systematic review to identify and assess the appropriateness and validity of multi-domain tools. [PDF]

Palliat Med, 2022
Mitchinson L, Chu C, Bruun A, Sisk AR, Armstrong M, Vindrola-Padros C, Kupeli N, Candy B, Stone P.   +8 more
europepmc   +1 more source