Results 81 to 90 of about 5,410,212 (366)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Can Librarians Play a Role in Bibliotherapy?

مدیریت اطلاعات سلامت, 2014
Bibliotherapy is one of the complementary methods of treatment to cure those suffering from mental or behavioral problems. This research attempted to answer the question:"Are present librarians competent to do bibliotherapy?" This study is a review type;
Seyyedeh Sedigheh Taherzadeh Mousavian, Zahed Bigdeli   +1 more
doaj  

The potential of arts therapies in Parkinson's disease rehabilitation: A comprehensive review

Heliyon
Background and purpose: Parkinson's disease (PD) causes a decline in motor function, cognitive decline, and impacts the mental health of patients. Due to the high cost and side effects of conventional treatments, the medical community has begun to ...
Yiyuan Li, Xuexing Luo, Aijia Zhang, Fangtian Ying, Jue Wang, Guanghui Huang   +5 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Attitudes pregnant women in Türkiye towards holistic complementary and alternative medicine and influencing factors: a web-based cross-sectional study

BMC Complementary Medicine and Therapies, 2023
Background Pregnant women turn to holistic complementary and alternative medicine to cope with problems associated with the changes they experience during pregnancy. This study aimed to determine the attitudes of pregnant women in Türkiye toward holistic
Burcu Küçükkaya, Hafsa Kübra Işık
doaj   +1 more source

Complementary therapies for bladder pain syndrome: a systematic review

International Urogynecology Journal, 2015
Introduction and hypothesisBladder pain syndrome is a difficult condition to treat. The purpose of this systematic review is to assess the effectiveness of various complementary therapies available for treatment.MethodsThis review was conducted in ...
T. Verghese, R. N. Riordain, R. Champaneria, P. Latthe   +3 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Literature Review of Complementary and Alternative Medicine Used Among Diabetes Mellitus Patients [PDF]

, 2019
Diabetes is a chronic disease that requires regular and sustainable health management that involves proper treatment. Some diabetic patients use CAM, as well as conventional medicine, to maintain their health and control their blood sugar.
Agil, M. (Mangestuti), Joeliantina, A. (Anita), Kusnanto, K. (Kusnanto), Qomaruddin, M. B. (M), Soedirham, O. (Oedojo)   +4 more
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