Results 131 to 140 of about 168,680 (293)
Madelyn J Blake,1 Clifford J Steer2 1Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA; 2Departments of Medicine, and Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, MN ...
Steer CJ, Blake MJ
core
The Büchi Complementation Saga
, 2007 The complementation problem for nondeterministic word automata has numerous applications in formal verification. In particular, the language-containment problem, to which many verification problems are reduced, involves complementation.
Moshe Y. Vardi
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A corpus-based analysis of light verb constructions with MAKE and DO in British English
KalbotyraThe comparison of light verb constructions with the verbs make and do has not received much attention. The present paper is an attempt to contribute to the study of these constructions.
Judita Giparaitė
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Competition in the Complementation of Old English Control Verbs with Oblique Marking: A Corpus Analysis [PDF]
The aim of this article is to explain the syntactic competition found in the complementation of Old English Prevent verbs. The competition on argumenthood involves linked verbal predications and linked nominal predications.
Ana Elvira Ojanguren López +1 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Chinese LinguisticsABSTRACT: In this article, it is argued that a purely functional and semantically bleached shì in Mandarin could in many contexts be best analyzed as a complementizer. As such, it is comparable to English that and functions as an (optional) introducer of the clausal arguments.
openaire +2 more sources