Results 91 to 100 of about 152,670 (312)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Metabolites, 2020 Metabolic flux analysis requires both a reliable metabolic model and reliable metabolic profiles in characterizing metabolic reprogramming. Advances in analytic methodologies enable production of high-quality metabolomics datasets capturing isotopic flux.
Huan Jin +2 more
doaj +1 more source
On List Coloring with Separation of the Complete Graph and Set System Intersections [PDF]
, 2022 Olivier Togni +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Color code techniques in rainbow connection
Electronic Journal of Graph Theory and Applications, 2018 Let G be a graph with an edge k-coloring γ : E(G) → {1, …, k} (not necessarily proper). A path is called a rainbow path if all of its edges have different colors.
Fendy Septyanto, Kiki A. Sugeng
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Quantum Feasibility Labeling for NP-complete Vertex Coloring Problem [PDF]
, 2023 Junpeng Zhan
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On $(t-1)$-colored paths in $t$-colored complete graphs
Bulletin of the Belgian Mathematical Society - Simon Stevin, 2018 Given $t$ distinct colors, the $t$ subsets of $t-1$ colors are ordered in some arbitrary manner. Let $(G_1, G_2, \ldots, G_t)$ be graphs. The $(t-1)$-chromatic Ramsey number, denoted by $r_{t-1}^t(G_1, G_2, \ldots, G_t)$, is defined to be the least number $n$ such that if the edges of the complete graph $K_n$ are colored in any fashion with $t$ colors,
openaire +3 more sources