Results 91 to 100 of about 7,985,327 (252)

Deep learning-based predictive model for pathological complete response to neoadjuvant chemotherapy in breast cancer from biopsy pathological images: a multicenter study

Frontiers in Physiology
Introduction: Early predictive pathological complete response (pCR) is beneficial for optimizing neoadjuvant chemotherapy (NAC) strategies for breast cancer.
Huancheng Zeng, Siqi Qiu, Siqi Qiu, Shuxin Zhuang, Xiaolong Wei, Jundong Wu, Ranze Zhang, Kai Chen, Zhiyong Wu, Zhemin Zhuang   +9 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Effect of adjuvant chemotherapy on the oncological outcome of rectal cancer patients with pathological complete response

Background Locally advanced rectal cancer is typically treated using a combination of neoadjuvant chemoradiotherapy and total mesorectal resection. While achieving pathological complete response following neoadjuvant chemoradiotherapy has been recognized
Zhongxue Fu, Qican Deng, Xin Wu, Jianguo Yang, Yong Cheng   +4 more
core   +1 more source

The need for effective radiosentitizing agents: experience in patients with complete pathological response

, 2011
Chemoradiation therapy is now considered the preferred initial treatment strategy for distal rectal cancer because of the observation of better local disease control and significant tumor downstaging.
PEREZ, Rodrigo O., Angelita Habr-Gama, HABR-GAMA, Angelita, JULIAO, Guilherme P. Sao, GAMA-RODRIGUES, Joaquim, Rodrigo O. Perez, Igor Proscurshim, Guilherme P. São Julião, Joaquim Gama-Rodrigues, PROSCURSHIM, Igor   +9 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Uni and multivariate logistic regression models of patient- and disease-related features and pathological complete response.

, 2016
Uni and multivariate logistic regression models of patient- and disease-related features and pathological complete response.
Irene Terrenato (95244), Maddalena Barba (82927), Giuseppe Sanguineti (2547409), Angiolo Gadducci (91555), Marcella Mottolese (85368), Patrizia Vici (85361), Francesca Sperati (95245), Ruggero De Maria (129963), Marcello Maugeri-Saccà (435396), Simonetta Buglioni (85363), Barbara Antoniani (2547412), Ilio Vitale (82793), Monica Bartucci (2547418), Cristina Vincenzoni (2547421), Rosanna Dattilo (2547415), Domenico Sergi (435399), Laura Pizzuti (435400), Mariantonia Carosi (2547406), Luigi Di Lauro (435401), Luciano Mariani (435398), Enrico Vizza (73331), Teresa Gamucci (477362)   +21 more
core   +1 more source

Factors Affecting Pathological Complete Response in Locally Advanced Breast Cancer Cases Receiving Neoadjuvant Therapy: A Comprehensive Literature Review

European Journal of Breast Health
Determining pathological complete response (pCR) could be an important step in planning individual treatment, hence improving the prognosis in terms of survival. Achieving breast pCR not only improves survival but is also linked to a disease-free axilla,
Munaser Alamoodi
doaj   +1 more source

Favorable short-term survival in locally advanced cervical cancer with optimal pathological response after neoadjuvant chemoimmunotherapy: a real-world analysis

Frontiers in Immunology
BackgroundThis real-world study evaluated short-term survival outcomes and potential risk factors in patients with locally advanced cervical cancer (LACC) who achieved optimal pathological response (OPR) following neoadjuvant chemoimmunotherapy and ...
Luyang Zhao, Qingzhi Zhai, Wenbo Zhang, Liang Wen, Xiaoyu Fu, Xiufeng Xie, Xiangshu Jin, Nina Zhang, Yuanguang Meng, Li’an Li, Chenglei Gu   +10 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source