Results 111 to 120 of about 594,966 (315)
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh+5 more
wiley +1 more source
This experiment was conducted to study the effects of katuk leave meal on sexual maturity in Japanese quail. Three hundred female Japanese quails, with 4 weeks age, were assigned into a completely randomized design with 4 treatments i.e., R1 (diet with ...
R Wiradimadja+3 more
doaj +2 more sources
This work aimed to study the effect of the Calophyllum brasiliense seed coat on the seed germination process. To this end, three experiments were conducted in laboratory, greenhouse and screenhouse. From a total of six treatments, five are related to the
Valquíria Aparecida Mendes de Jesus+5 more
doaj +1 more source
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban+12 more
wiley +1 more source
Bagging time of ‘Prata-anã’ banana regarding anthracnose control
The aim of this work was to determine the bagging time of ‘Prata Anã’ banana in order to reduce anthracnose disease. Treatments consisted of protection of banana bunches with TNT bags at emission, 30, 60, 90 and 120 days after emission and of unpacked ...
Martielle Batista Fernandes+5 more
doaj +1 more source
Sum of Us: Strategyproof Selection from the Selectors [PDF]
We consider directed graphs over a set of n agents, where an edge (i,j) is taken to mean that agent i supports or trusts agent j. Given such a graph and an integer k\leq n, we wish to select a subset of k agents that maximizes the sum of indegrees, i.e.,
Alon, Noga+3 more
core +2 more sources
Decrypting cancer's spatial code: from single cells to tissue niches
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik+4 more
wiley +1 more source
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi+2 more
wiley +1 more source