Results 101 to 110 of about 307,001 (266)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Difference sequence space m(M,ø,Ämn,p) F of fuzzy real numbers
Mathematical Modelling and Analysis, 2008 The difference sequence space m(M, ø, Äm n,p) F of fuzzy real numbers for both 1 ≤ p < 8 and 0
Binod Chandra Tripathy, Stuti Borgohain
doaj
Complete Methods for Building Complete Applications [PDF]
, 2007 nformation systems development methods (ISDMs) produce a product, the application, by following a development process model. We argue that in failing to produce the application process model that supports the application product, ISDMs only address part of the IS development problem. Additionally, we show that there is, in fact, a range of abstractions
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
L -Random and Fuzzy Normed Spaces and Classical Theory
Cubo, 2010 In this paper we study L-random and L-fuzzy normed spaces and prove open mapping and closed graph theorems for these spaces.En este artículo estudiamos espacios normados L-random and L-fuzzy.
DONAL O’REGAN, REZA SAADATI
doaj
Dense In Situ Underwater 3D Reconstruction by Aggregation of Successive Partial Local Clouds
Remote SensingAssessing the completeness of an underwater 3D reconstruction on-site is crucial as it allows for rescheduling acquisitions, which capture missing data during a mission, avoiding additional costs of a subsequent mission.
Loïca Avanthey, Laurent Beaudoin
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Remote SensingIn recent decades, the creation and availability of Voluntary Geographic Information (VGI) have changed the paradigm associated with the production of Geospatial Information (GI), since, due to its free access, citizens can view, analyse, process, and ...
Elisabete S. Veiga Monteiro +1 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source