Results 141 to 150 of about 323,193 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A longitudinal study of the association of adolescent polydrug use, alcohol use and high school non-completion

, 2015
AIMS: Failure to complete high school predicts substantial economic and social disadvantage in adult life. The aim of this study was to determine the longitudinal association of mid-adolescent polydrug use and high school non-completion, relative to ...
AB Kelly (14465106), SA Hemphill (14463303), R Smith (7738349), Tracy Evans-Whipp (15902936), WD Hall (9854222), John Toumbourou (13076802), GC Chan (11759936), GC Patton (7722857), RF Catalano (14463300)   +8 more
core  

No doctoral studies without hurdles: A review on pathways to prevent dropouts

Interdisciplinary Journal of Education Research
Traditionally, doctoral studies take at least three to six years of full-time study, depending on the country and institution. However, the number of doctoral students who complete their studies in the prescribed time does not meet the expectations of ...
Shadreck Muchaku, Marizvikuru Mwale, Grey Magaiza, Malose Moses Tjale   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Improving transfer student Baccalaureate completion through higher education centers

, 2018
According to the National Center for Education Statistics (Aud et al., 2013), only 10.6% of students who started at a two-year institution in the 2003-2004 year successfully completed a baccalaureate degree from a four-year institution within six years ...
Gonzalez, Jeffery M.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Factors influencing completion of treatment among pulmonary tuberculosis patients

, 2019
Xue-Hui Fang,1,* Yi-Lin Dan,2,* Jie Liu,1 Lei Jun,1 Zhi-Ping Zhang,3 Xiao-Hong Kan,1 Dong-Chun Ma,1 Guo-Cui Wu41Department of Science and Education, Anhui Provincial TB Institute, Hefei, Anhui, People’s Republic of China; 2Department of ...
Dan YL, Wu GC, Liu J, Ma DC, Jun L, Fang XH, Kan XH, Zhang ZP   +7 more
core  

“Getting to the End”: Psychological Factors Influencing Research Higher Degree Completion [PDF]

, 2011
There is increasing interest concerning progress and completion rates of postgraduate research students. This paper examines factors relating to completion and non-completion identified in Australian and international research, and takes a critical ...
Jonathan Norton
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source