Results 251 to 260 of about 4,051,827 (361)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The effect of sample type on genetic testing completion in pediatric congenital hearing loss patients. [PDF]

J Community Genet
Adams B, Lichten L, Heyward A, Govil N.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis. [PDF]

Front Nutr
Wu J, Xu K, Yin M, Ding X, Wang T, Zhang Q, Wu X, Xiao N.   +7 more
europepmc   +1 more source

Accounting Treatment of Contractors’ Dues and its Impact on Project Completion and Government Accounting System: Evidence from Iraq

Akram Azzaoui
openalex   +1 more source

Complete issue

CAML Review / Revue de l'ACBM, 2010
openaire   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Beyond the check-up: how well-child exams, pediatric specialists, and provider recommendations can close HPV vaccine gaps for Chinese American Teens. [PDF]

Cancer Causes Control
Zhu L, Li X, Liu EZ, Siu PT, Zhai S, Pan C, Cao N, Ma GX.   +7 more
europepmc   +1 more source

Ldcl: Large Language Model-Driven Dual-View Contrastive Learning for Temporal Knowledge Graph Completion

Yuchao Zhang, Xiangjie Kong, Yinghui Liu, Shangfei Zheng, Guojiang Shen, Jianxin Li   +5 more
openalex   +1 more source

Graph Stochastic Neural Process for Inductive Few-shot Knowledge Graph Completion [PDF]

Zicheng Zhao, Linhao Luo, Shirui Pan, Chengqi Zhang, Chen Gong   +4 more
openalex   +1 more source