Results 51 to 60 of about 265,994 (263)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Single Machine Scheduling Problem with Interval Processing Times and Total Completion Time Objective
Algorithms, 2018 We consider a single machine scheduling problem with uncertain durations of the given jobs. The objective function is minimizing the sum of the job completion times.
Yuri N. Sotskov, Natalja G. Egorova
doaj +1 more source
Quantum Information and Computation, 2014 In this paper we give an overview of the quantum computational complexity class QMA and a description of known QMA-complete problems to date (The reader is invited to share more proven QMA-complete problems with the author). Such problems are believed to be difficult to solve, even with a quantum computer, but have the property that if a purported ...
openaire +2 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Problem with Objectives of Minimizing Resource Costs and Minimizing Project Completion Time [PDF]
Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2013 A Resource Investment Problem is a project scheduling problem recently considered. In this issue, in contrast with other project scheduling, the project availability of needed resources level is considered decision variable and the goal is to find a ...
amir abas najafii +2 more
doaj
Time-Minimized Offloading for Mobile Edge Computing Systems
IEEE Access, 2019 Task offloading is the hot issue for current network. The rapid development of intelligent terminals brings new opportunity for offloading. This paper studies the problem of task offloading in a mobile edge computing system, where both the fixed devices ...
Xinyu Qiu, Linbo Zhai, Hua Wang
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
The art gallery problem is ∃ ℝ-complete
Proceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018 The Art Gallery Problem (AGP) is a classic problem in computational geometry, introduced in 1973 by Victor Klee. Given a simple polygon 풫 and an integer k , the goal is to decide if there exists a set G of k guards within 풫 such that
Mikkel Abrahamsen +2 more
openaire +8 more sources
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source