Results 111 to 120 of about 78,358 (306)

Visualizing Complex Cardiac Arrhythmias

Journal of Nippon Medical School, 2008
Yasushi, Miyauchi, Yu-ki, Iwasaki, Reiko, Okazaki, Hiroshige, Murata, Teppei, Yamamoto, Ayano, Matsumoto, Yoshinori, Kobayashi, Takao, Katoh, Kyoichi, Mizuno   +8 more
openaire   +3 more sources

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Stellate ganglion, inflammation, and arrhythmias: a new perspective on neuroimmune regulation

Frontiers in Cardiovascular Medicine
Current research on the stellate ganglion (SG) has shifted from merely understanding its role as a collection of neurons to recognizing its importance in immune regulation.
Qiulian Lei, Zefei Jiang, Yu Shao, Xinghong Liu, Xiaoping Li, Xiaoping Li   +5 more
doaj   +1 more source

Coherent mapping: A step toward physiological mapping of complex arrhythmias?

, 2020
Ramanathan Parameswaran, Jonathan M. Kalman, Geoffrey Lee   +2 more
openalex   +2 more sources

P-269 Quality of life in adults with previously operated complex congenital heart disease: Do arrhythmias make it worse? [PDF]

, 2003
Thilo Heimes, A. Kumin, David Tüller, Thomas Stüber, Courtney L. Vetter, M. Rotter, Etienne Delacrétaz   +6 more
openalex   +1 more source

Targeting Ventricular Arrhythmias in Non-Ischemic Patients: Advances in Diagnosis and Treatment

Diagnostics
Ventricular arrhythmias (VAs) in non-ischemic cardiomyopathy (NICM) present significant clinical challenges due to their diverse etiologies and complex arrhythmogenic substrates, which differ from those in ischemic heart disease.
Laura Adina Stanciulescu, Maria Dorobantu, Radu Vatasescu   +2 more
doaj   +1 more source

Long-term risk assessment in athletes with complex ventricular arrhythmias [PDF]

Paolo Compagnucci, Michela Casella, Maria Lucia Narducci, Edoardo Conte, Michela Cammarano, Gemma Pelargonio, Daniele Andreini, Vincenzo Palmieri, Gianluca Pontone, Federico Guerra, Andrea Natale, C Tondo, Filippo Crea, Paolo Zeppilli, Antonio Dello Russo   +14 more
openalex   +1 more source