Results 101 to 110 of about 43,499 (332)

Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies

Epilepsia Open, EarlyView.
Abstract Objective Genetic testing is now included in the diagnostic assessment of childhood onset epilepsies. We evaluated the yield of a targeted next generation sequencing (TNGS) panel dedicated to pediatric epilepsies. Methods We tested by TNGS panel 1000 consecutive patients presenting with childhood onset epilepsies and including mainly patients ...
Giulia Barcia, Nicole Chemaly, Stéphanie Gobin‐Limballe, Emma Losito, Mélodie Aubart, Eugénie Sarda, Zahra Assouline, Pauline Plante‐Bordeneuve, Marie Hully, Remi Barrois, Christine Barnerias, Doxa Sareidaki, Delphine Coste Zeitoun, Monika Eisermann, Cécile Fourrage, Sylvain Hanein, Marlène Rio, Nathalie Boddaert, Isabelle Desguerre, Anna Kaminska, Julie Steffann, Rima Nabbout   +21 more
wiley   +1 more source

Clinical analysis on the relationship between febrile seizure and epileptic etiology in adolescents

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To analyze the clinical characteristics and treatment of young epileptic patients with febrile seizure (FS) history, and to investigate the relationship between febrile seizure and epileptic attack in adolescents.
Ran AO, Xiao-bing SHI, Xiang-qing WANG, Sen-yang LANG   +3 more
doaj  

Neurodiagnostic Evaluation of a Child with First Complex Febrile Seizure [PDF]

Journal of Krishna Institute of Medical Sciences University, 2016
Background: Febrile seizure is the most common type of childhood seizure and complex febrile seizure has been associated with the risk of epilepsy. The neurodiagnostic evaluation of a child with first CFS is still unclear.
Arpita S Thakker, Krishna A. Shetye
doaj  

A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome [PDF]

, 2009
A follow-up study of a large Utah family with significant linkage to chromosome 2q24 led us to identify a new febrile seizure (FS) gene, SCN9A encoding Na(v)1.7.
Claes, Lieve R. F., Dahle, E. Jill, De Jonghe, Peter, Dixon, Missy, Filloux, Francis, Gurnett, Christina, Leppert, Mark F, Pappas, Chris, Peiffer, Andy, Pruess, Timothy H, Singh, Nanda A, Thompson, Joel, White, H. Steve   +12 more
core   +4 more sources

SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications

Epilepsia Open, EarlyView.
Abstract A large number of cases with Dravet syndrome (DS) has been attributed to SCN1A loss of function (LOF), whereas SCN1A gain‐of‐function (GOF) causes early infantile developmental and epileptic encephalopathy (EIDEE) and familial hemiplegic migraine 3.
Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue   +13 more
wiley   +1 more source

Clinical risk factors of febrile seizure in children in a university hospital in Bushehr port

Iranian South Medical Journal, 2007
Background: Although the majority of febrile seizures are benign, it is clinically important to understand the underlying mechanism. In this study, we investigated characteristics of febrile convulsion and factors related to its recurrence and its ...
Anahita Sanaei Dashty, Allah karam Akhlaghi, Raha Pazoki   +2 more
doaj  

Risk factor for febrile seizures [PDF]

Praxis Medica, 2014
Febrile seizures are the most frequent neurological disorder in the childhood. According to American Academy of Pediatrics (AAP), they have been defined as seizures provoked by high temperature in children aged between 6 months and 5 years, without ...
Odalović Dragica, Čukalović M., Katanić N., Odalović A., Jakšić D.   +4 more
doaj   +1 more source

Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing

Epilepsia Open, EarlyView.
Abstract Epilepsy represents a significant medical challenge, with a third of patients failing to achieve seizure freedom despite the use of multiple different anti‐seizure medications (ASM). Drug resistance is common in genetically caused epilepsies. Patients are faced with repeated, long‐lasting, and frequently frustrating drug testing, necessitating
Emma V. Töfflinger, Konstantin L. Makridis, M.‐Marcel Heim, David Owald, Angela M. Kaindl   +4 more
wiley   +1 more source

Incidence of Meningitis in Children Aged 6-18 Months with First Febrile Seizure and Good General Condition Referring to Imam Hossein and Amin Hospitals, Isfahan, Iran, from May 2016 to March 2017

مجله دانشکده پزشکی اصفهان, 2018
Background: Febrile seizure is the most common type of childhood seizures that occurs in about 3-5 percent of children between the ages of six months and six years.
Jafar Nasiri, Fatemeh Mokhtarian
doaj   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source