Results 221 to 230 of about 43,499 (332)

Semiological differences between children and adults with temporal lobe epilepsy: a video-EEG based multivariate analysis. [PDF]

open access: yesFront Neurol
Mei A   +11 more
europepmc   +1 more source

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 1965-1974, July 2025.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis   +12 more
wiley   +1 more source

High frequency deep brain stimulation of the hippocampus in a rat model for temporal lobe epilepsy [PDF]

open access: yes, 2006
Boon, Paul   +9 more
core   +1 more source

Fever as a Catalyst for Life‐Threatening Arrhythmias in Brugada Syndrome: A Rare Case of Brugada Syndrome Unmasked in a Young Male

open access: yesClinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Brugada syndrome (BrS) is a rare, genetically predisposed arrhythmic disorder associated with an elevated risk of sudden cardiac death (SCD) due to ventricular arrhythmias. Fever is a recognized trigger that can unmask the Type 1 Brugada electrocardiogram (ECG) pattern and precipitate life‐threatening arrhythmias, even in individuals without ...
Ibrahim Khalil, Md. Imran Hossain
wiley   +1 more source

Complex Febrile Seizures, Lumbar Puncture, and Central Nervous System Infections: A National Perspective

open access: bronze, 2018
Jane Lee   +4 more
openalex   +1 more source

Long‐term follow‐up and combined Phase 2 results of eprenetapopt and azacitidine in patients with TP53 mutant MDS/AML

open access: yesHemaSphere, Volume 9, Issue 7, July 2025.
Abstract TP53 gene mutations (mTP53) represent a distinct molecular cohort with poor outcomes. Eprenetapopt (APR‐246) is a novel, first‐in‐class small molecule that reactivates p53 and targets cellular redox balance, ultimately inducing apoptosis and ferroptosis in mTP53 cancer cells.
David A. Sallman   +32 more
wiley   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

open access: yesMedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang   +12 more
wiley   +1 more source

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