Results 61 to 70 of about 17,619 (303)

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Febrile seizures: mechanisms and relationship to epilepsy. [PDF]

, 2009
Studies of febrile seizures have been driven by two major enigmas: first, how these most common of human seizures are generated by fever has not been known.
Alheim, Amy L. Brewster, Annegers, Annegers, Aram, Audenaert, Balestrino, Ban, Baram, Baram, Barone, Bender, Bender, Berg, Berg, Berg, Berg, Berg, Brewster, Brewster, Cartmell, Cartmell, Cendes, Chang, Chen, Chen, Chen, Céline M. Dubé, Dubé, Dubé, Dubé, Dubé, Dzhala, Escayg, French, Fukuda, Gatti, Germano, Hamati-Haddad, Harkin, Haspolat, Heida, Heida, Holtzman, Ichiyama, Isaac, Jiang, Kamal, Kang, Lahat, Le Van Quyen, Lemmens, Morimoto, Morimoto, Moser, Nelson, Pellegrini-Giampietro, Provenzale, Racine, Raspall-Chaure, Richichi, Sanchez, Scantlebury, Schuchmann, Shibasaki, Shinnar, Stafstrom, Takao, Tallie Z. Baram, Tan, Theodore, Toth, Tütüncüoğlu, Verity, Verity, Verity, Vezzani, Virta, Wallace, Zerr   +79 more
core   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

The Role of Seizure-Related SEZ6 as a Susceptibility Gene in Febrile Seizures

Neurology Research International, 2011
Sixty cases of febrile seizures from a Chinese cohort had previously been reported with a strong association between variants in the seizure-related (SEZ) 6 gene and febrile seizures. They found a striking lack of genetic variation in their controls.
John C. Mulley, Xenia Iona, Bree Hodgson, Sarah E. Heron, Samuel F. Berkovic, Ingrid E. Scheffer, Leanne M. Dibbens   +6 more
doaj   +1 more source

Randomized, controlled trial of ibuprofen syrup administered during febrile illnesses to prevent febrile seizure recurrences [PDF]

, 1998
OBJECTIVES: Febrile seizures recur frequently. Factors increasing the risk of febrile seizure recurrence include young age at onset, family history of febrile seizures, previous recurrent febrile seizures, time lapse since ...
Derksen-Lubsen, G. (Gerarda), Habbema, J.D.F. (Dik), Moll, H.A. (Henriëtte), Steyerberg, E.W. (Ewout), Stuijvenberg, M. (Margriet) van   +4 more
core   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

A Follow Up Study of Admitted Febrile Seizure Patients with Respect to Recurrence of Febrile or Afebrile Seizures

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2009
Introduction: Febrile seizure is the most common type of seizure that occurs in 3– 4% of children below the age of 5 years. The purpose of this study was to determine the frequency of recurrence of febrile and afebrile seizures after the first febrile ...
F Mir-Naseri, A Shajari, Z Islami, M Golestan, S Akhavan Karbasi, R Fallah   +5 more
doaj  

Diazepam intermitente e fenobarbital contínuo para tratamento da recorrência de convulsões febris: uma revisão sistemática com metanálise [PDF]

, 2003
Convulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous ...
Atallah, Álvaro Nagib, Carvalho, Luciane Bizari Coin de, Castro, Aldemar Araujo, Masuko, Alice Hatsue, Prado, Gilmar Fernandes do, Prado, Lucila Bizari Fernandes do, Santos, Gustavo Rocha   +6 more
core   +2 more sources

Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. [PDF]

, 1991
Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood.
Bender, Roland A, Dubé, Celine, Gonzalez-Vega, Rebeca, Mina, Erene W, Baram, Tallie Z   +4 more
core   +3 more sources