Abstract Objective Addressing the poorly understood impact of pediatric epilepsy on neurodevelopment, this large‐scale study delineates age‐ and sex‐stratified neurostructural trajectories in magnetic resonance imaging (MRI)‐negative pediatric epilepsy to identify periods of maximal developmental divergence from healthy controls.
Yingfan Wang +10 more
wiley +1 more source
Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study [PDF]
BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized not only by deficits in communication and social interactions but also a high rate of co-occurring disorders, including metabolic abnormalities, gastrointestinal and ...
Conturo, Thomas E +4 more
core +2 more sources
Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov +10 more
wiley +1 more source
Clinical analysis on the relationship between febrile seizure and epileptic etiology in adolescents
Objective To analyze the clinical characteristics and treatment of young epileptic patients with febrile seizure (FS) history, and to investigate the relationship between febrile seizure and epileptic attack in adolescents.
Ran AO +3 more
doaj
Febrile seizures Familial risk factors, outcome and preventive use of antipyretic drugs [PDF]
Febrile seizures (FS) occur in early childhood during a febrile illness. A typical or simple FS is characterized by a sudden loss of consciousness with either stiffening and myoclonic jerking or total loss of muscle tone.
Esch, A. (Adrianus) van
core +1 more source
The pointing gesture in 12 month old infants born pre-term [PDF]
Universidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of ...
Gomes, M. +3 more
core +1 more source
Abstract Objective Pathogenic variants in γ‐aminobutyric acid type A (GABAA) receptor genes have been associated with a wide spectrum of neurological disorders. We aimed to delineate the clinical trajectories associated with gain‐of‐function (GoF) and loss‐of‐function (LoF) variants in GABRB2 and GABRB3, and to develop a risk‐prediction model for gross
Sebastian Ortiz +73 more
wiley +1 more source
Clinical risk factors of febrile seizure in children in a university hospital in Bushehr port
Background: Although the majority of febrile seizures are benign, it is clinically important to understand the underlying mechanism. In this study, we investigated characteristics of febrile convulsion and factors related to its recurrence and its ...
Anahita Sanaei Dashty +2 more
doaj
Experimental febrile seizures increase dendritic complexity of newborn dentate granule cells [PDF]
SummaryObjectiveFebrile seizures (FS) are fever‐associated convulsions, being the most common seizure disorder in early childhood. A subgroup of these children later develops epilepsy characterized by a hyperexcitable neuronal network in the hippocampus.
RAIJMAKERS, Marjolein +7 more
openaire +4 more sources
Does acquired epileptogenesis in the immature brain require neuronal death. [PDF]
Because epilepsy often occurs during development, understanding the mechanisms by which this process takes place (epileptogenesis) is important. In addition, the age-specificity of seizures and epilepsies of the neonatal, infancy, and childhood periods ...
Baram, Tallie Z +2 more
core +2 more sources

