Results 151 to 160 of about 2,087,732 (267)

Modular Scalable Synthetic Gene Circuits for Complex Functions Within Minimal Computational Layers in Human Cells. [PDF]

Nat Commun
Roas K, Kovalski I, Mouhadeb O, Aminov T, Weinstein-Marom H, Nissim L.   +5 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The Znf711-Phf8 complex functions as a transcriptional rheostat essential for neutrophil development. [PDF]

Haematologica
Tan S, Qian H, Wang H, Chen Y, Yuan H, Liu X, Wang Y, De Thé H, Zhu J, Zhou J.   +9 more
europepmc   +1 more source

Pyruvate kinase M2: A simple molecule with complex functions. [PDF]

Free Radic Biol Med, 2019
Alquraishi M, Puckett DL, Alani DS, Humidat AS, Frankel VD, Donohoe DR, Whelan J, Bettaieb A.   +7 more
europepmc   +1 more source

The <i>Glycine max</i> Conserved Oligomeric Golgi (COG) Complex Functions During a Defense Response to <i>Heterodera glycines</i>. [PDF]

Front Plant Sci, 2020
Lawaju BR, Niraula P, Lawrence GW, Lawrence KS, Klink VP.   +4 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production. [PDF]

EMBO J
Feng Z, Wang L, Chen S, Cao S, Lei M, Yang X, Ma K, Yu S, Hu H, Zheng K, Xu X, Zheng Q, Wang S, Hu W, Lim CY.   +14 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

LUBAC modulates CBM complex functions downstream of TRAF6 in T cells. [PDF]

Nat Commun
Graß C, Ober F, Sixt C, Moud BN, Antoshkina I, Eberstadt F, Puhach A, Avar G, Keßler A, O'Neill TJ, Seeholzer T, Kranich J, Brocker T, Lammens K, Menden MP, Zielinski CE, Krappmann D.   +16 more
europepmc   +1 more source