Results 221 to 230 of about 2,087,732 (267)

Evolution and Adaptation of the Mitochondrial Protein Import Machinery in Parasitic Protists: Beyond the Canonical TOM Complex. [PDF]

Int J Mol Sci
Anvari E, Daryabor G, Sedigh A, Rashidi S, Nguewa P.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Complexity of Clathrin Coat Dynamics in Endocytosis. [PDF]

Traffic
Boinet AL, Roux A, Kaksonen M.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Maximum Entropy on the Complex Probability Framework. [PDF]

Entropy (Basel)
Tapiador FJ.
europepmc   +1 more source

An Fc Receptor and IgA Functional Signature Identifies TB Disease in Children Living With HIV. [PDF]

J Pediatric Infect Dis Soc
Kang YJ, Wang N, Malik AA, Lu P, Grossman A, Njuguna I, Maleche-Obimbo E, LaCourse SM, Slyker J, Wamalwa D, John-Stewart GC, Wang C, Cranmer LM, Lu LL.   +13 more
europepmc   +1 more source

Beyond Resource Expansion: Building Resilient Hospital Surge Capacity for Sustained Crisis Response. [PDF]

Healthcare (Basel)
Li X, Xu J, Wang X, Zhang Y.
europepmc   +1 more source

Distinct functions of mammalian RAD51 paralogs in genome maintenance. [PDF]

Biochem Soc Trans
Dwivedi HK, Bhattacharya D, Kadupatil S, Nagaraju G.   +3 more
europepmc   +1 more source

The frontal cortex in mental disorders. [PDF]

World Psychiatry
Robbins TW.
europepmc   +1 more source