Results 81 to 90 of about 438,100 (274)
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source
Group actions, non-Kähler complex manifolds and SKT structures
Complex Manifolds, 2018 We give a construction of integrable complex structures on the total space of a smooth principal bundle over a complex manifold, with an even dimensional compact Lie group as structure group, under certain conditions.
Poddar Mainak, Thakur Ajay Singh
doaj +1 more source
Tunnel complexes of 3–manifolds [PDF]
Algebraic & Geometric Topology, 2011 The author defines, for each 3-manifold \(M\) and natural number \(t\), the \(t\)-tunnel complex \({\mathcal T}_t(M)\), whose vertices are knots in \(M\) of tunnel number at most \(t\), and \(k+1\) vertices span a \(k\)-simplex of \({\mathcal T}_t(M)\) if there is a \(\theta\)-curve of \(t+2\) edges in \(M\) such that \(M - \text{Int}((N(\theta))\) is ...
openaire +2 more sources
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Examples of Compact Simply Connected Holomorphic Symplectic Manifolds Which Are Not Formal
AxiomsIn this paper, we prove that the complex four dimensional compact holomorphic symplectic manifold we found earlier is not formal. This gives another strong consequence that it is not a topological Kähler manifold. We also conjecture that this is true for
Daniel Guan
doaj +1 more source
Learning a Robust Local Manifold Representation for Hyperspectral Dimensionality Reduction
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2017 Local manifold learning has been successfully applied to hyperspectral dimensionality reduction in order to embed nonlinear and nonconvex manifolds in the data.
Danfeng Hong +2 more
doaj +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source