Results 71 to 80 of about 7,730,013 (301)

Complex multiplication cycles and Kudla-Rapoport divisors [PDF]

, 2012
We study the intersections of special cycles on a unitary Shimura variety of signature (n-1,1) and show that the intersection multiplicities of these cycles agree with Fourier coefficients of Eisenstein series. The results are new cases of conjectures of
Benjamin Howard
semanticscholar   +1 more source

Complex Multiplication in Twistor Spaces [PDF]

International Mathematics Research Notices, 2020
AbstractDespite the transcendental nature of the twistor construction, the algebraic fibres of the twistor space of a K3 surface share certain arithmetic properties. We prove that for a polarised K3 surface with complex multiplication, all algebraic fibres of its twistor space away from the equator have complex multiplication as well.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Phenotypic and genetic analysis of udder health using SCC in Valle del Belice dairy sheep

Italian Journal of Animal Science, 2010
Intramammary infections (IMI) are a complex of inflammatory diseases which are defined as an inflammation of the mammary gland resulting from the introduction and multiplication of pathogenic micro-organisms.
P. Giaccone, A. Zumbo, M.T. Sardina, V. Riggio, B. Portolano   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Rigorous Extension of the Schönhage-Strassen Integer Multiplication Algorithm Using Complex Interval Arithmetic [PDF]

Electronic Proceedings in Theoretical Computer Science, 2010
Multiplication of n-digit integers by long multiplication requires O(n^2) operations and can be time-consuming. In 1970 A. Schoenhage and V. Strassen published an algorithm capable of performing the task with only O(n log(n)) arithmetic operations over ...
Thomas Steinke, Raazesh Sainudiin
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Implementation of Multidigit Multiplication Basing on Discrete Cosine and Sine Transforms

Кібернетика та комп'ютерні технології, 2021
Introduction. The emergence of new parallel computing systems such as multi-core processors, clusters, distributed systems, due to the solution of various applications in different spheres.
Andrii Tereshchenko, Valeriy Zadiraka
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source