Results 71 to 80 of about 500,615 (284)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Complex Multiplication in Twistor Spaces [PDF]
International Mathematics Research Notices, 2020 AbstractDespite the transcendental nature of the twistor construction, the algebraic fibres of the twistor space of a K3 surface share certain arithmetic properties. We prove that for a polarised K3 surface with complex multiplication, all algebraic fibres of its twistor space away from the equator have complex multiplication as well.
openaire +2 more sources
On the supersingular reduction of K3 surfaces with complex multiplication [PDF]
, 2017 We study the good reduction modulo p of K3 surfaces with complex multiplication. If a K3 surface with complex multiplication has good reduction, we calculate the Picard number and the height of the formal Brauer group of the reduction.
Ito, Kazuhiro
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Tropical algebra for noise removal and optimal control
Journal of Low Frequency Noise, Vibration and Active Control, 2023 Algorithms for noise removal are either complex or ineffective, and the optimal control with inequality constrains makes the algorithm even more complex.
Chun-Mei Gong, Jiao Peng, Jing Wang
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Phenotypic and genetic analysis of udder health using SCC in Valle del Belice dairy sheep
Italian Journal of Animal Science, 2010 Intramammary infections (IMI) are a complex of inflammatory diseases which are defined as an inflammation of the mammary gland resulting from the introduction and multiplication of pathogenic micro-organisms.
P. Giaccone +4 more
doaj +1 more source
A public–private partnership to speed up potato breeding
Open Agriculture, 2020 The process to develop potato cultivars is complex and lengthy due to numerous reasons, viz., tetrasomic inheritance with heterozygous nature, large number of phenotypic recurrent selections, low efficiency of selections in early generations, slow ...
Sharma Neeraj +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source