Results 111 to 120 of about 8,270,809 (301)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Meromorphic Function of Fuzzy Complex Variables

open access: yesJournal of New Theory, 2018
The fuzzy complex set is a fuzzy set whose values lies in the unit circle jzj · 1 in the complex plane. The Nevanlinna characteristic function playes an important role in the theory of entire and meromorphic function. In this paper we introduce
Arindam Jha
doaj  

Erlangen Program at Large-1: Geometry of Invariants

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2010
This paper presents geometrical foundation for a systematic treatment of three main (elliptic, parabolic and hyperbolic) types of analytic function theories based on the representation theory of SL_2(R) group. We describe here geometries of corresponding
Vladimir V. Kisil
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Design and Optimization of GEMM for Complex Numbers on Ascend NPU

open access: yesComputers
It is widely acknowledged that General Matrix Multiplication (GEMM) serves as a foundational kernel across numerous application domains. Complex numbers exhibit distinctive mathematical properties that enable their widespread adoption across engineering ...
Erkun Zhang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Error Analysis in Third-Year Complex Number Topics: A Study of Undergraduate Mathematics Students in a Nigerian University

open access: yesInterdisciplinary Journal of Education
This study investigates error patterns made by undergraduate mathematics education students at a Nigerian university when solving problems on third-year complex number topics.
Gafari Lukumon   +7 more
doaj   +1 more source

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