Results 201 to 210 of about 8,270,809 (301)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Integrating network toxicology and transcriptomics to identify CXCL8, EGFR, PTPRC, MYC, and AKT1 as key targets of microplastic-induced miscarriage. [PDF]

Medicine (Baltimore)
Niu L, Zhang X, Chen Y, Song G, Li J, Xia Y.   +5 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Structural basis for the synaptic adhesion protein ELFN1-mediated modulation of mGlu7. [PDF]

Protein Cell
Lin S, Feng Y, Shui S, Chen M, Chu X, Yi C, Han S, Zhao Q, Wu B.   +8 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak. [PDF]

Nat Commun
Nabukeera KC, Luakanda-Ndelemo G, Semawule S, Ayitewala A, Adroba-Tandele P, Walakira A, Amuri-Aziza A, Jansen D, Galiwango R, Kinganda-Lusamaki E, Tebba A, Ngandu C, Ssemaganda A, Tshiani-Mbaya O, Kanyerezi S, Kyokushaba J, Akil-Bandali P, Makoha C, Oundo HR, Kimbonza S, Balinandi S, Mukadi-Bamuleka D, Nakintu V, Nsio J, Mugerwa I, Kadobera D, Euriene D, Mulangu S, Ayouba A, Eliu M, Gidudu S, Kyobe Bosa H, Wayengera M, Rimoin AW, Lubwama B, Kagirita A, Ahuka-Mundeke S, Mwamba D, Kambugu A, Kaleebu P, Happi C, Liesenborghs L, Carroll MW, Maes P, Nachega JB, Peeters M, Akilimali P, Bahatungire R, Muruta A, Kindrachuk J, Rambaut A, Kyabayinze D, Olaro C, Vercauteren K, Muyembe-Tamfum JJ, Nabadda S, Atwine D, Jjingo D, Wawina-Bokalanga T, Mbala-Kingebeni P, Ssewanyana I.   +60 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The HydroGym reinforcement learning platform for fluid dynamics. [PDF]

Nature
Lagemann C, Mokbel S, Gondrum M, Rüttgers M, Wang Y, Suárez P, Paehler L, Bezgin DA, Buhendwa AB, Callaham JL, Ahnert S, Zolman N, Shao X, Loiseau JC, Adams NA, Meinke M, Schröder W, Lagemann K, Lagemann E, Vinuesa R, Brunton SL.   +20 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Theoretical estimates on the expected number of mutations needed to reconstruct clonal lineage trees. [PDF]

Bioinform Adv
Bristy NA, Schwartz R.
europepmc   +1 more source