Results 51 to 60 of about 1,585,178 (233)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Method and Software Implementation of Kinematic Analysis of a Rocker Mechanism
Механика машин, механизмов и материаловAn analytical method of kinematic analysis of the rocker mechanism of the reaping part of a grain harvester using the theory of complex numbers, as well as an algorithm and its software implementation are presented.
Andrey V. Kotov, Dmitriy G. Krol
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Axiomatic of Fuzzy Complex Numbers
Axioms, 2012 Fuzzy numbers are fuzzy subsets of the set of real numbers satisfying some additional conditions. Fuzzy numbers allow us to model very difficult uncertainties in a very easy way.
Angel Garrido
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Журнал Белорусского государственного университета: Математика, информатика, 2018 For the first time the contact problem of elasticity theory for the rigid (not deformable) disk and elastic plane with a hole was approximately solved using the method of analytic functions without the application of singular equations.
Alexander S. Kravchuk +1 more
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Kuwait Journal of ScienceThis work introduces complex hybrid numbers, an extension of hybrid numbers, which are defined as Z = z0 + z1i + z2ɛ + z3ℎ where zi are complex numbers and iℎ = −ℎi = i + ɛ.
Furkan Seçgin +2 more
doaj +1 more source
Hardware realizations of arithmetic with complex integer numbers on PLD-base [PDF]
Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2008 Hardware realizations of arithmetic with complex integer numbers were proposed. The generators of sine and cosine with different frequency were used to make behavior stand.
Opanasenko V. N. +2 more
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