Results 171 to 180 of about 1,777,027 (265)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Structure and Interactions in 1:2 K⁺-Crown Ether Complexes via Gas-Phase Cold UV and IR Spectroscopy. [PDF]

J Phys Chem Lett
Inokuchi Y, Rizzo TR.
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

The optimization of low Earth orbit satellite constellation visibility with genetic algorithm for improved navigation potential. [PDF]

Sci Rep
Qin C, Gao Y, Wang Y.
europepmc   +1 more source

ESTIMATION OF THE DIRECTIONS OF INCIDENT PLANE WAVES IN CASE THAT THE SOUND SOURCES ARE COMPLEX PURE TONE : Basic study of the error of the directions

, 2001
Noboru Kamiakito, Yasuhiro Yamashita, Takefumi Zaima, Masanao Owaki, Takeshi Sugiyama, Katsunori Sawa   +5 more
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping. [PDF]

Nat Commun
De Magalhaes Pinheiro I, Dawson JRD, Calo N, Paolini-Bertrand M, Akondi KB, Tan G, Handel TM, Kufareva I, Hartley O.   +8 more
europepmc   +1 more source

Quasiconformal mappings and minimal Martin boundary of p-sheeted unlimited covering surfaces of the complex plane [PDF]

, 2005
Hiroaki Masaoka, Shigeo Segawa
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Fourier expansions of complex‐valued Eisenstein series on finiteupper half planes [PDF]

, 2006
Anthony Shaheen, Audrey Terras
openalex   +1 more source