Results 291 to 300 of about 19,967,816 (378)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A variational framework for residual-based adaptivity in neural PDE solvers and operator learning. [PDF]

NPJ Artif Intell
Toscano JD, Chen DT, Ooomen V, Darbon J, Karniadakis GE.   +4 more
europepmc   +1 more source

Changes in redox potential of a nickel-pincer complex bearing reactive secondary thioamide units: Changes caused by deprotonation/protonation reactions on addition of NEt3 and DBU

, 2011
Teratani Takuya, Koizumi Take-aki, Takakazu Yamamoto, KANBARA Takaki   +3 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Letter to the Editor Regarding "Impact of Anisotropic Conduction and Premature Atrial Contraction on the Fractionated Atrial Potentials". [PDF]

J Arrhythm
Ibrahim H, Riaz L, Hasnain M.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Observations of Isolated Mobile Au-Br and Au-S Surface Complexes on Au(100) Electrodes. [PDF]

Angew Chem Int Ed Engl
Yang C, Magnussen OM.
europepmc   +1 more source

The study of biomethane potential from the Anaerobic Digestion and Co-digestion of complex Organic Wastes in Batch and CSTR modes

, 2019
Asma Khan
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Extended Rice-Thomson analysis and atomistic simulations revealing grain boundary effects on fracture in refractory high-entropy alloys. [PDF]

Proc Natl Acad Sci U S A
Wang W, Cook DH, Chen X, Kumar P, Minor AM, Rao SI, Asta M, Ritchie RO, Farkas D.   +8 more
europepmc   +1 more source