Results 111 to 120 of about 13,893,592 (304)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Facile Formation of Multifunctional Biomimetic Hydrogel Fibers for Sensing Applications
GelsTo face the challenges in preparing hydrogel fibers with complex structures and functions, this study utilized a microfluidic coaxial co-extrusion technique to successfully form functional hydrogel fibers through rapid ionic crosslinking.
Mengwei Jia +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure of complex thinking -Manual teacher-
, 2013 La presente investigación se desarrolla a partir del interés de los autores por darles a sus estudiantes la posibilidad de tener una estructura de pensamiento que les permita tener éxito en los diferentes procesos de resolución de problemas que se les ...
Redondo, Johan Manuel +5 more
core +1 more source
High Voltage, 2018 UHF (ultra high frequency) method has been widely used in PD (partial discharge) detection for its high sensitivity. The resonance, distortion, and attenuation appearing in the propagation process of UHF signals in GIS (gas insulated switchgear) will ...
Minxia Shi +8 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Planning an Healthcare Network: the case of Clinical Laboratories in Sicily
, 2014 Healthcare centers, private and public, are responsible for serving health demand of the population. Typically their respective geographical location and size is the result of a complex interaction between epidemiological, historical and economical ...
Sergio Pagano, Pierpaolo Cavallo
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source