Results 141 to 150 of about 13,893,592 (304)
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Impact of removing nodes on the controllability of complex networks [PDF]
, 2017 Complexity theory has been used to study a wide range of systems in biology and nature but also business and socio-technical systems, e.g., see [1].
Moschoyiannis, Sotiris +1 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Three dimensional structure of the light-harvesting chlorophyll a/b protein complex from plant chloroplasts [PDF]
, 2002 The light-harvesting chlorophyll a/b protein complex (LHC-II) is the major collector of solar energy in all plants and it binds about half of the chlorophyll in green plants.
Lamborghini, Matteo, Lamborghini, M.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Multiplicative Complexity and Algebraic Structure
Journal of Computer and System Sciences, 1983 AbstractThe classical structure theory of an (associative unitary) algebra A over a field F is invoked to determine upper bounds on the (bilinear) multiplicative complexity π(A) of A over F. The upper bound problem for matrix multiplication over a finite extension F of the rational numbers is related to the multiplicative complexity problem for a ...
openaire +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Structure of Complex, Large-scale Governance Systems
, 2018 Large-scale governance systems can be considered complex systems. They encompass organizations involved in a multitude of substantive issues, on various jurisdictional levels and in different phases of the policy process. General complexity theory posits
Angst, Mario
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