Results 131 to 140 of about 3,687,194 (237)

Understanding how to create healthier places: A qualitative study exploring the complex system of urban development decision-making. [PDF]

Health Place, 2023
Le Gouais A, Bates G, Callway R, Kwon HR, Montel L, Peake-Jones S, White J, Hasan MN, Koksal C, Barnfield A, Bondy K, Ayres S.   +11 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Demystifying the commercial determinants of health in antimicrobial resistance through complex system dynamics. [PDF]

Health Promot Int
Smith C, Hitch J, Savic L.
europepmc   +1 more source

Cognition Without Neural Representation: Dynamics of a Complex System. [PDF]

Front Psychol, 2021
Hipólito I.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Multimodal data generative fusion method for complex system health condition estimation. [PDF]

Sci Rep
Kang W, Zhang X, Zhang J, Chen X, Huang H, He B, Qin W, Zhu H.   +7 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria. [PDF]

Elife
Mukherjee SD, Batagello C, Adler A, Agudelo J, Zampini A, Suryavanshi M, Nguyen A, Orr T, Dearing D, Monga M, Miller AW.   +10 more
europepmc   +1 more source

Green innovation and income inequality: A complex system analysis.

Struct Chang Econ Dyn, 2022
Napolitano L, Sbardella A, Consoli D, Barbieri N, Perruchas F.   +4 more
europepmc   +1 more source

The Cannabis Plant as a Complex System: Interrelationships between Cannabinoid Compositions, Morphological, Physiological and Phenological Traits. [PDF]

Plants (Basel), 2023
Naim-Feil E, Elkins AC, Malmberg MM, Ram D, Tran J, Spangenberg GC, Rochfort SJ, Cogan NOI.   +7 more
europepmc   +1 more source