Results 251 to 260 of about 7,947,791 (315)

Generative learning for forecasting the dynamics of high-dimensional complex systems. [PDF]

Nat Commun
Gao H, Kaltenbach S, Koumoutsakos P.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Thinking about inequalities in physical activity as an emergent feature of complex systems. [PDF]

Int J Behav Nutr Phys Act
Jones SM, Porroche-Escudero A, Shearn K, Hunter RF, Garcia L.   +4 more
europepmc   +1 more source

Deep Reinforcement Learning and Transfer Learning-Based Intelligent Robot Control System: Automated Optimization and Tuning for Complex Manufacturing Tasks [PDF]

Qinxia Ma, Yichen Xu
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Hypernetwork modeling and topology of high-order interactions for complex systems. [PDF]

Proc Natl Acad Sci U S A
Feng L, Gong H, Zhang S, Liu X, Wang Y, Che J, Dong A, Griffin CH, Gragnoli C, Wu J, Yau ST, Wu R.   +11 more
europepmc   +1 more source

Research on the Construction of Scientific and Technological Innovation Emergency System for Major Public Health Emergencies from the Perspective of Complex Adaptive System [PDF]

思文 张
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Industry influence on public health policy formulation in the UK: a complex systems approach. [PDF]

Health Promot Int
van den Akker A, Fabbri A, Bertscher A, Gilmore AB, Knai C, Cavill N, Rutter H.   +6 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source