Results 21 to 30 of about 2,361,537 (287)
Engineering complex systems [PDF]
Nature, 2004 The emergent properties of complex systems are far removed from the traditional preoccupation of engineers with design and purpose.
openaire +2 more sources
Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization
Scientific Reports, 2017 HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using
Alexandra Boeske +8 more
doaj +1 more source
Journal of The Royal Society Interface, 2017 Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades.
openaire +2 more sources
SARS-CoV-2 receptor-binding domain deep mutational AlphaFold2 structures
Scientific Data, 2023 Leveraging recent advances in computational modeling of proteins with AlphaFold2 (AF2) we provide a complete curated data set of all single mutations from each of the 7 main SARS-CoV-2 lineages spike protein receptor binding domain (RBD) resulting in ...
Oz Kilim +4 more
doaj +1 more source
International Journal of Geophysics, 2023 The assumption of a homogeneous elastic half-space model is widely used to model the earth’s deformation. However, the homogeneous assumption would not accurately reflect the complexity of the shallow crust.
Alvina K. Kuncoro +2 more
doaj +1 more source
Nature Communications, 2017 Understanding the dynamics of supramolecular architectures without using labels is crucial for developing advanced biosystems. Here, the authors show kinetic hydrogen/deuterium exchange profiles for a series of water-soluble supramolecular polymers.
Xianwen Lou +8 more
doaj +1 more source
The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states
Nature Communications, 2021 Models of brain organisation can overlook the role of the autonomic nervous system in cognitive processes. Here the authors show a link between the ascending arousal system and both low dimensional neural dynamics and internal shifts in conscious ...
Brandon R. Munn +3 more
doaj +1 more source
A stochastic view on surface inhomogeneity of nanoparticles
Nature Communications, 2019 Determining the spatial arrangement of molecules on a nanoparticle’s surface is key to understanding its interactions. Here, the authors use dSTORM imaging and probabilistic modelling to map the distribution of fluorophores on a nanoparticle, finding ...
R. A. J. Post +6 more
doaj +1 more source
Wavefront Shaping with Varying Degrees of Freedom [PDF]
EPJ Web of ConferencesOptical wavefront shaping employs the linearity of scattering to focus light through scattering media using spatial modulation. By selectively switching off weakly-contributing segments, we significantly improve optimization speeds with minimal intensity
Hubert Maël +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia +7 more
wiley +1 more source