Results 51 to 60 of about 8,616,832 (292)

Trauma-Focused Tuning in to Kids: Evaluation in a Clinical Service

Children, 2021
This study evaluated the Tuning in to Kids (TIK) parenting program delivered in a clinical setting with 77 parents and caregivers (hereafter referred to as “parents”) of children who had experienced complex trauma.
Sophie S. Havighurst, Jessica L. Murphy, Christiane E. Kehoe   +2 more
doaj   +1 more source

Healing the Past by Nurturing the Future—co-designing perinatal strategies for Aboriginal and Torres Strait Islander parents experiencing complex trauma: framework and protocol for a community-based participatory action research study

BMJ Open, 2019
Introduction Child maltreatment and other traumatic events can have serious long-term physical, social and emotional effects, including a cluster of distress symptoms recognised as ‘complex trauma’.
C. Chamberlain, Graham Gee, S. Brown, Judith Atkinson, H. Herrman, Deirdre Gartland, Karen Glover, Yvonne Clark, S. Campbell, F. Mensah, C. Atkinson, Sue E. Brennan, H. McLachlan, T. Hirvonen, Danielle Dyall, N. Ralph, S. Hokke, J. Nicholson   +17 more
semanticscholar   +1 more source

The Impact of the COVID‐19 Pandemic on the Well‐Being of People With Borderline Personality Disorder: A National Australian Study

Mental Health Science
Social isolation due to the COVID‐19 pandemic was a significantly destabilizing factor for people with borderline personality disorder (BPD). The aim of this study was to investigate the well‐being of Australians diagnosed with BPD during the initial ...
Parvaneh Heidari, Jillian H. Broadbear, Marita Mohammadshahi, Farzaneh Foroughinia, Rita Brown, Sathya Rao   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A systematic review of psychological therapies and treatment outcomes for complex PTSD and childhood abuse

, 2023
Research indicates that current interventions for Complex Post-Traumatic Stress Disorder (CPTSD) have poor treatment outcomes, particularly for survivors of childhood abuse (CA). The review aims to investigate symptom reduction, recovery/remission rates,
Dallas, T, Freeman, A
core  

Navigating parenthood in people living with borderline personality disorder: a meta-ethnography

Borderline Personality Disorder and Emotion Dysregulation
Background Emotional dysregulation, impulsivity, and interpersonal difficulties are some of the severe and debilitating symptoms of borderline personality disorder (BPD). Parenting while living with BPD is associated with high levels of parental distress,
Karthika Kasiviswanathan, Jessica Lee, Sathya Rao, Jillian H. Broadbear   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Increasing access to psychological therapy on acute mental health wards: staff and patient experiences of a stepped psychological intervention

BMC Psychiatry
Background Psychological therapies are recommended for people with serious mental health problems. However, access is limited, particularly in inpatient mental health settings.
Isobel Johnston, Dawn Edge, Paul Wilson, Adele Beinaraviciute, Sandra Bucci, Richard Drake, Gill Gilworth, Gillian Haddock, Fritz Handerer, Sonalia Kaur, Karina Lovell, Helen Morley, Owen Price, Mica Samji, Katherine Berry   +14 more
doaj   +1 more source

Olecranon With Concomitant Radial Head Fracture: A Case Series of Fifteen Patients

Frontiers in Surgery, 2022
IntroductionSimultaneous olecranon and radial head fractures are rare injuries and due to this factor, the outcome of the selected therapy is not widely studied.
Konstantinos Ditsios, Charalampos Pitsilos, Triantafyllos Katsimentzas, Panagiotis Konstantinou, Panagiotis Christidis, Pericles Papadopoulos   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source