Results 111 to 120 of about 3,456,187 (322)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Studying the stressed state of elastic medium using the argument functions of a complex variable

Eastern-European Journal of Enterprise Technologies, 2019
Based on the argument function method and the complex variable function method, we have derived the generalizing solutions to a flat problem on the theory of elasticity using the invariant differential ratios capable of closing the result for the set ...
V. Chigirinsky, O. Naumenko
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

On generation of Julia sets, Mandelbrot sets and biomorphs via a modification of the viscosity approximation method

Results in Control and Optimization
Iterative methodology has been demonstrated to be an achievement in the age of fractals. A novel method based on the viscosity approximation approach, one of the most popular iterative techniques for identifying non-linear operator fixed points, for ...
Rimsha Babar, Wutiphol Sintunavarat
doaj   +1 more source

Combinatorial Optimization Method for Operation of Pumping Station with Adjustable Blade and Variable Speed Based on Experimental Optimization of Subsystem

Advances in Mechanical Engineering, 2014
A decomposition-dynamic programming aggregation method based on experimental optimization for subsystem was proposed to solve mathematical model of optimal operation for single pumping station with adjustable blade and variable speed.
Yi Gong, Jilin Cheng
doaj   +1 more source

Variable Selection Methods for Multivariate, Functional, and Complex Biomedical Data in the AI Age

CoRR
Many problems within personalized medicine and digital health rely on the analysis of continuous-time functional biomarkers and other complex data structures emerging from high-resolution patient monitoring. In this context, this work proposes new optimization-based variable selection methods for multivariate, functional, and even more general outcomes
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

RESEARCH OF OPENING DISPLACEMENTS FOR TWO CRACKS EMANATING FROM A CIRCULAR HOLE IN AN INFINITE PLATE UNDER PRESSURE ON PART OF CRACK SURFACE

Jixie qiangdu, 2019
The purpose of this paper is to research problems of cracks at a circular hole, which is a common crack configuration in aircraft structures. The Muskhelishvili complex function method and the Cauchy integral method are combined to develop crack surface ...
ZHU QingYu, SONG Bo, ZENG ZhaoYang
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source